TY - JOUR
T1 - High diadenosine tetraphosphate (Ap4A) level at initiation of S phase in the naturally synchronous mitotic cycle of Physarum polycephalum
AU - Weinmann-Dorsch, Christa
AU - Pierron, Gerard
AU - Wick, Roland
AU - Sauer, Helmut
AU - Grummt, Friedrich
PY - 1984/1/1
Y1 - 1984/1/1
N2 - Levels of the diadenosine tetraphosphate Ap4A are high during exponential growth of Physarum, decrease during encystment (spherulation) and increase again during excystment. Consistently, a rapid 8-30-fold increase in Ap4A level occurs at entry into S phase of the mitotic cycle and is maintained during the first half of genome replication. The elevated Ap4A level depends significantly on ongoing DNA replication and is completely sensitive to the protein synthesis inhibitor cycloheximide administered either before or after initiation of S phase.
AB - Levels of the diadenosine tetraphosphate Ap4A are high during exponential growth of Physarum, decrease during encystment (spherulation) and increase again during excystment. Consistently, a rapid 8-30-fold increase in Ap4A level occurs at entry into S phase of the mitotic cycle and is maintained during the first half of genome replication. The elevated Ap4A level depends significantly on ongoing DNA replication and is completely sensitive to the protein synthesis inhibitor cycloheximide administered either before or after initiation of S phase.
UR - http://www.scopus.com/inward/record.url?scp=0021714246&partnerID=8YFLogxK
U2 - 10.1016/0014-4827(84)90778-X
DO - 10.1016/0014-4827(84)90778-X
M3 - Article
C2 - 6489457
AN - SCOPUS:0021714246
SN - 0014-4827
VL - 155
SP - 171
EP - 177
JO - Experimental Cell Research
JF - Experimental Cell Research
IS - 1
ER -