High-Dose Chemotherapy in Children with Newly Diagnosed Medulloblastoma

Lucie Lafay-Cousin; Christelle Dufour

doi:10.3390/cancers14030837

High-Dose Chemotherapy in Children with Newly Diagnosed Medulloblastoma

Lucie Lafay-Cousin, Christelle Dufour

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

Abstract

High-dose chemotherapy with stem cell rescue has been used as an adjuvant therapy or as salvage therapy to treat pediatric patients with brain tumors, and to avoid deleterious side effects of radiotherapy in infants and very young children. Here, we present the most recent trials using high-dose chemotherapy regimens for medulloblastoma in children, and we discuss their contribu-tion to improved survival and describe their toxicity profile and limitations.

Original language	English
Article number	837
Journal	Cancers
Volume	14
Issue number	3
DOIs	https://doi.org/10.3390/cancers14030837
Publication status	Published - 1 Feb 2022

Keywords

Childhood
High-dose chemotherapy
Newly diagnosed medulloblastoma
Trials

Access to Document

10.3390/cancers14030837

Cite this

@article{fcf3fd6ef527425b85ed64e6e06154b7,

title = "High-Dose Chemotherapy in Children with Newly Diagnosed Medulloblastoma",

abstract = "High-dose chemotherapy with stem cell rescue has been used as an adjuvant therapy or as salvage therapy to treat pediatric patients with brain tumors, and to avoid deleterious side effects of radiotherapy in infants and very young children. Here, we present the most recent trials using high-dose chemotherapy regimens for medulloblastoma in children, and we discuss their contribu-tion to improved survival and describe their toxicity profile and limitations.",

keywords = "Childhood, High-dose chemotherapy, Newly diagnosed medulloblastoma, Trials",

author = "Lucie Lafay-Cousin and Christelle Dufour",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = feb,

day = "1",

doi = "10.3390/cancers14030837",

language = "English",

volume = "14",

journal = "Cancers",

issn = "2072-6694",

number = "3",

}

TY - JOUR

T1 - High-Dose Chemotherapy in Children with Newly Diagnosed Medulloblastoma

AU - Lafay-Cousin, Lucie

AU - Dufour, Christelle

PY - 2022/2/1

Y1 - 2022/2/1

N2 - High-dose chemotherapy with stem cell rescue has been used as an adjuvant therapy or as salvage therapy to treat pediatric patients with brain tumors, and to avoid deleterious side effects of radiotherapy in infants and very young children. Here, we present the most recent trials using high-dose chemotherapy regimens for medulloblastoma in children, and we discuss their contribu-tion to improved survival and describe their toxicity profile and limitations.

AB - High-dose chemotherapy with stem cell rescue has been used as an adjuvant therapy or as salvage therapy to treat pediatric patients with brain tumors, and to avoid deleterious side effects of radiotherapy in infants and very young children. Here, we present the most recent trials using high-dose chemotherapy regimens for medulloblastoma in children, and we discuss their contribu-tion to improved survival and describe their toxicity profile and limitations.

KW - Childhood

KW - High-dose chemotherapy

KW - Newly diagnosed medulloblastoma

KW - Trials

UR - http://www.scopus.com/inward/record.url?scp=85124030751&partnerID=8YFLogxK

U2 - 10.3390/cancers14030837

DO - 10.3390/cancers14030837

M3 - Review article

AN - SCOPUS:85124030751

SN - 2072-6694

VL - 14

JO - Cancers

JF - Cancers

IS - 3

M1 - 837

ER -

High-Dose Chemotherapy in Children with Newly Diagnosed Medulloblastoma

Abstract

Keywords

Access to Document

Other files and links

Cite this