Human dendritic cells in cancer

Egle Kvedaraite, Florent Ginhoux

Research output: Contribution to journalReview articlepeer-review

137 Citations (Scopus)

Abstract

Dendritic cells (DCs) are professional antigen-presenting cells, orchestrating innate and adaptive immunity during infections, autoimmune diseases, and malignancies. Since the discovery of DCs almost 50 years ago, our understanding of their biology in humans has increased substantially. Here, we review both antitumor and tolerogenic DC responses in cancer and discuss lineage-specific contributions by their functionally specialized subsets, including the conventional DC (cDC) subsets cDC1 and cDC2, the newly described DC3, and the plasmacytoid DCs (pDCs), focusing on the human setting. In addition, we review the lineage-unrestricted “mature DCs enriched in immunoregulatory molecules” (mregDC) state recently described across different human tumors.

Original languageEnglish
Article numbereabm9409
JournalScience Immunology
Volume7
Issue number70
DOIs
Publication statusPublished - 1 Apr 2022
Externally publishedYes

Cite this