TY - JOUR
T1 - Identification of a functional DNA binding site for the SREBP-1c transcription factor in the first intron of the human caspase-2 gene
AU - Logette, E.
AU - Solary, E.
AU - Corcos, L.
N1 - Funding Information:
The authors wish to thank Drs T. Osborne and I. Dugail for their gifts of SREBP expression plasmids and Drs C. Le Jossic-Corcos, P. Bournot and A. Bettaieb for their encouragements and suggestions. E. Logette was a recipient of a fellowship from the Ministry of Research and Education. This work was supported by the Ligue Nationale Française Contre le Cancer, the Conseil Général de Bourgogne and the INSERM.
PY - 2005/12/30
Y1 - 2005/12/30
N2 - Sterol Regulatory Element Binding Proteins (SREBP) are transcription factors that regulate lipid synthesis. We have shown recently that the human CASP-2 gene, encoding procaspase-2, was under the positive control of SREBP-2 that transactivates several responsive elements in the promoter region. We describe here the function of an additional SREBP-responsive element located in the first intron. Remarkably, this site is uniquely responsive to SREBP-1c that is mainly involved in fatty acids synthesis. This observation, together with our recent findings, strengthens the notion that the CASP-2 gene belongs to the SREBP-responsive gene battery in human cells.
AB - Sterol Regulatory Element Binding Proteins (SREBP) are transcription factors that regulate lipid synthesis. We have shown recently that the human CASP-2 gene, encoding procaspase-2, was under the positive control of SREBP-2 that transactivates several responsive elements in the promoter region. We describe here the function of an additional SREBP-responsive element located in the first intron. Remarkably, this site is uniquely responsive to SREBP-1c that is mainly involved in fatty acids synthesis. This observation, together with our recent findings, strengthens the notion that the CASP-2 gene belongs to the SREBP-responsive gene battery in human cells.
KW - Human caspase-2
KW - Intron
KW - Lipid
KW - SREBP
KW - Transcriptional regulation
UR - http://www.scopus.com/inward/record.url?scp=31044440029&partnerID=8YFLogxK
U2 - 10.1016/j.bbalip.2005.11.006
DO - 10.1016/j.bbalip.2005.11.006
M3 - Article
C2 - 16387548
AN - SCOPUS:31044440029
SN - 1388-1981
VL - 1738
SP - 1
EP - 5
JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
IS - 1-3
ER -