Imatinib in the treatment of solid tumours

Florence Duffaud; Axel Le Cesne

doi:10.1007/s11523-008-0101-x

Imatinib in the treatment of solid tumours

Florence Duffaud, Axel Le Cesne

Research output: Contribution to journal › Review article › peer-review

46 Citations (Scopus)

Abstract

The extraordinary success of imatinib in gastrointestinal stromal tumors (GIST) represents a model for molecularly targeted therapy for other solid tumors. Research is currently going to identify the molecular basis of mechanisms of action and drug resistance. In this article, we review recent advances in the clinical management of patients with GISTs treated with imatinib, but also of patients with dermatofibrosarcoma protuberans, chordoma, aggressive fibromatosis, and some other common solid tumors treated with this drug. We reviewed the knowledge of the molecular mechanisms that are basic to imatinib effects in these tumors.

Original language	English
Pages (from-to)	45-56
Number of pages	12
Journal	Targeted Oncology
Volume	4
Issue number	1
DOIs	https://doi.org/10.1007/s11523-008-0101-x
Publication status	Published - 1 Jan 2009

Keywords

Aggressive fibromatosis
Chordoma
Dermatofibrosarcoma protuberans
Gatstrointestinal stromal tumors
Imatinib
Solid tumors

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10.1007/s11523-008-0101-x

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Imatinib in the treatment of solid tumours

Abstract

Keywords

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