Immunogenic cell death in cancer: concept and therapeutic implications

Lorenzo Galluzzi, Oliver Kepp, Erik Hett, Guido Kroemer, Francesco M. Marincola

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    50 Citations (Scopus)

    Abstract

    Mammalian cells responding to specific perturbations of homeostasis can undergo a regulated variant of cell death that elicits adaptive immune responses. As immunogenic cell death (ICD) can only occur in a precise cellular and organismal context, it should be conceptually differentiated from instances of immunostimulation or inflammatory responses that do not mechanistically depend on cellular demise. Here, we critically discuss key conceptual and mechanistic aspects of ICD and its implications for cancer (immuno)therapy.

    Original languageEnglish
    Article number162
    JournalJournal of Translational Medicine
    Volume21
    Issue number1
    DOIs
    Publication statusPublished - 1 Dec 2023

    Keywords

    • Antigenicity
    • CAR T cells
    • DAMPs
    • Immune checkpoint inhibitors
    • Pattern recognition receptors
    • Tumor microenvironment

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