Immunogenicity of cell death driven by immune effectors

Lorenzo Galluzzi, Giulia Petroni, Guido Kroemer

    Research output: Contribution to journalReview articlepeer-review

    13 Citations (Scopus)

    Abstract

    Whether cell death caused by T lymphocytes and natural killer (NK) cells would be immunogenic per se has been a matter of intense debate. Two back-to-back papers from the Melero's and Pardo's groups have now resolved this conundrum, demonstrating that T and NK cell-mediated cytotoxicity represents indeed a bona fide variant of immunogenic cell death.

    Original languageEnglish
    Article numbere000802
    JournalJournal for ImmunoTherapy of Cancer
    Volume8
    Issue number1
    DOIs
    Publication statusPublished - 5 Apr 2020

    Keywords

    • CD8-Positive T-Lymphocytes
    • cytotoxicity, immunologic
    • natural killer T-cells
    • receptors, chimeric antigen

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