Immunosuppression by Mutated Calreticulin Released from Malignant Cells

Peng Liu, Liwei Zhao, Friedemann Loos, Caroline Marty, Wei Xie, Isabelle Martins, Sylvie Lachkar, Bo Qu, Emmanuelle Waeckel-Énée, Isabelle Plo, William Vainchenker, Franck Perez, David Rodriguez, Carlos López-Otin, Peter van Endert, Laurence Zitvogel, Oliver Kepp, Guido Kroemer

    Research output: Contribution to journalArticlepeer-review

    84 Citations (Scopus)

    Abstract

    Mutations affecting exon 9 of the CALR gene can be found in many forms of cancer and lead to the calreticulin (CALR) protein that is released. Liu et al. have shown that extracellular CALR inhibits the phagocytosis by dendritic cells, exerts immunosuppressive effects, and suppresses the effect of anticancer immunotherapy.

    Original languageEnglish
    Pages (from-to)748-760.e9
    JournalMolecular Cell
    Volume77
    Issue number4
    DOIs
    Publication statusPublished - 20 Feb 2020

    Keywords

    • CD47 blockade
    • ICD
    • PD-1
    • RUSH
    • calreticulin
    • immunogenic cell death
    • immunosuppression
    • phagocytosis
    • retention using selective hooks

    Cite this