Immunosurveillance of Malignant Cells with Complex Karyotypes

Alejandro López-Soto; Segundo Gonzalez; Carlos López-Larrea; Guido Kroemer

doi:10.1016/j.tcb.2017.09.001

Immunosurveillance of Malignant Cells with Complex Karyotypes

Alejandro López-Soto, Segundo Gonzalez, Carlos López-Larrea, Guido Kroemer

Research output: Contribution to journal › Short survey › peer-review

11 Citations (Scopus)

Abstract

A wide array of cell-intrinsic surveillance mechanisms maintains the homeostasis of dividing cells and the integrity of the genome. Accumulating evidence also supports a role for cell-extrinsic mechanisms. Among them, the immune system, together with cell-autonomous checkpoint processes, eliminates cells that harbor unbalanced karyotypes generated by mitotic defects.

Original language	English
Pages (from-to)	880-884
Number of pages	5
Journal	Trends in Cell Biology
Volume	27
Issue number	12
DOIs	https://doi.org/10.1016/j.tcb.2017.09.001
Publication status	Published - 1 Dec 2017

Keywords

aneuploidy
cancer immunotherapy
hyperploidy
immune checkpoint
immunosurveillance
somatic copy-number alteration

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10.1016/j.tcb.2017.09.001

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title = "Immunosurveillance of Malignant Cells with Complex Karyotypes",

abstract = "A wide array of cell-intrinsic surveillance mechanisms maintains the homeostasis of dividing cells and the integrity of the genome. Accumulating evidence also supports a role for cell-extrinsic mechanisms. Among them, the immune system, together with cell-autonomous checkpoint processes, eliminates cells that harbor unbalanced karyotypes generated by mitotic defects.",

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note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

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AU - López-Soto, Alejandro

AU - Gonzalez, Segundo

AU - López-Larrea, Carlos

AU - Kroemer, Guido

PY - 2017/12/1

Y1 - 2017/12/1

N2 - A wide array of cell-intrinsic surveillance mechanisms maintains the homeostasis of dividing cells and the integrity of the genome. Accumulating evidence also supports a role for cell-extrinsic mechanisms. Among them, the immune system, together with cell-autonomous checkpoint processes, eliminates cells that harbor unbalanced karyotypes generated by mitotic defects.

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KW - aneuploidy

KW - cancer immunotherapy

KW - hyperploidy

KW - immune checkpoint

KW - immunosurveillance

KW - somatic copy-number alteration

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DO - 10.1016/j.tcb.2017.09.001

M3 - Short survey

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EP - 884

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 12

ER -

Immunosurveillance of Malignant Cells with Complex Karyotypes

Abstract

Keywords

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