Improvement of immunogenic chemotherapy by STAT3 inhibition

Heng Yang; Takahiro Yamazaki; Federico Pietrocola; Heng Zhou; Laurence Zitvogel; Yuting Ma; Guido Kroemer

doi:10.1080/2162402X.2015.1078061

Improvement of immunogenic chemotherapy by STAT3 inhibition

Heng Yang, Takahiro Yamazaki, Federico Pietrocola, Heng Zhou, Laurence Zitvogel, Yuting Ma, Guido Kroemer

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The inhibition of STAT3 may exert cell-autonomous cytotoxic and cytostatic effects, yet may also stimulate anticancer immunosurveillance through the neutralization of immunosuppressive circuitries. In addition, STAT3 inhibition in cancer cells may stimulate the type 1 interferon response elicited by anthracyclines. This pathway results in an enhanced chemotherapy-associated anticancer immune response with improved therapeutic efficacy. Hence, combination therapies that include immunogenic cell death (ICD) inducers and STAT3 inhibitors can be envisaged.

Original language	English
Journal	OncoImmunology
Volume	5
Issue number	2
DOIs	https://doi.org/10.1080/2162402X.2015.1078061
Publication status	Published - 1 Feb 2016

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10.1080/2162402X.2015.1078061

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AU - Pietrocola, Federico

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AU - Zitvogel, Laurence

AU - Ma, Yuting

AU - Kroemer, Guido

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AB - The inhibition of STAT3 may exert cell-autonomous cytotoxic and cytostatic effects, yet may also stimulate anticancer immunosurveillance through the neutralization of immunosuppressive circuitries. In addition, STAT3 inhibition in cancer cells may stimulate the type 1 interferon response elicited by anthracyclines. This pathway results in an enhanced chemotherapy-associated anticancer immune response with improved therapeutic efficacy. Hence, combination therapies that include immunogenic cell death (ICD) inducers and STAT3 inhibitors can be envisaged.

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Improvement of immunogenic chemotherapy by STAT3 inhibition

Abstract

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