TY - JOUR
T1 - Inflammation-related marker profiling of dietary patterns and all-cause mortality in the melbourne collaborative cohort study
AU - Li, Sherly X.
AU - Hodge, Allison M.
AU - MacInnis, Robert J.
AU - Bassett, Julie K.
AU - Ueland, Per M.
AU - Midttun, Øivind
AU - Ulvik, Arve
AU - Rinaldi, Sabina
AU - Meyer, Klaus
AU - Navionis, Anne Sophie
AU - Shivappa, Nitin
AU - Hébert, James R.
AU - Flicker, Leon
AU - Severi, Gianluca
AU - Jayasekara, Harindra
AU - English, Dallas R.
AU - Vineis, Paolo
AU - Southey, Melissa C.
AU - Milne, Roger L.
AU - Giles, Graham G.
AU - Dugué, Pierre Antoine
N1 - Publisher Copyright:
© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition. All rights reserved.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Background: Nutritional epidemiology research using self-reported dietary intake is prone to measurement error. Objective methods are being explored to overcome this limitation. Objectives: We aimed to examine 1) the association between plasma markers related to inflammation and derive marker scores for dietary patterns [Mediterranean dietary score (MDS), energy-adjusted Dietary Inflammatory Index (E-DIITM), Alternative Healthy Eating Index 2010 (AHEI)] and 2) the associations of these marker scores with mortality. Methods: Weighted marker scores were derived from the cross-sectional association between 30 plasma markers and each dietary score (assessed using food-frequency questionnaires) using linear regression for 770 participants in the Melbourne Collaborative Cohort Study (aged 50–82 y). Prospective associations between marker scores and mortality (n = 249 deaths) were assessed using Cox regression (median follow-up: 14.4 y). Results: The MDS, E-DII, and AHEI were associated (P < 0.05) with 9, 14, and 11 plasma markers, respectively. Healthier diets (higher MDS and AHEI, and lower anti-inflammatory, E-DII) were associated with lower concentrations of kynurenines, neopterin, IFN-γ, cytokines, and C-reactive protein. Five of 6 markers common to the 3 dietary scores were components of the kynurenine pathway. The 3 dietary-based marker scores were highly correlated (Spearman ρ: –0.74, –0.82, and 0.93). Inverse associations (for 1-SD increment) were observed with all-cause mortality for the MDS marker score (HR: 0.84; 95% CI: 0.72–0.98) and the AHEI marker score (HR: 0.76; 95% CI: 0.66–0.89), whereas a positive association was observed with the E-DII marker score (HR: 1.18; 95% CI: 1.01–1.39). The same magnitude of effect was not observed for the respective dietary patterns. Conclusions: Markers involved in inflammation-related processes are associated with dietary quality, including a substantial overlap between markers associated with the MDS, the E-DII, and the AHEI, especially kynurenines. Unfavorable marker scores, reflecting poorer-quality diets, were associated with increased mortality.
AB - Background: Nutritional epidemiology research using self-reported dietary intake is prone to measurement error. Objective methods are being explored to overcome this limitation. Objectives: We aimed to examine 1) the association between plasma markers related to inflammation and derive marker scores for dietary patterns [Mediterranean dietary score (MDS), energy-adjusted Dietary Inflammatory Index (E-DIITM), Alternative Healthy Eating Index 2010 (AHEI)] and 2) the associations of these marker scores with mortality. Methods: Weighted marker scores were derived from the cross-sectional association between 30 plasma markers and each dietary score (assessed using food-frequency questionnaires) using linear regression for 770 participants in the Melbourne Collaborative Cohort Study (aged 50–82 y). Prospective associations between marker scores and mortality (n = 249 deaths) were assessed using Cox regression (median follow-up: 14.4 y). Results: The MDS, E-DII, and AHEI were associated (P < 0.05) with 9, 14, and 11 plasma markers, respectively. Healthier diets (higher MDS and AHEI, and lower anti-inflammatory, E-DII) were associated with lower concentrations of kynurenines, neopterin, IFN-γ, cytokines, and C-reactive protein. Five of 6 markers common to the 3 dietary scores were components of the kynurenine pathway. The 3 dietary-based marker scores were highly correlated (Spearman ρ: –0.74, –0.82, and 0.93). Inverse associations (for 1-SD increment) were observed with all-cause mortality for the MDS marker score (HR: 0.84; 95% CI: 0.72–0.98) and the AHEI marker score (HR: 0.76; 95% CI: 0.66–0.89), whereas a positive association was observed with the E-DII marker score (HR: 1.18; 95% CI: 1.01–1.39). The same magnitude of effect was not observed for the respective dietary patterns. Conclusions: Markers involved in inflammation-related processes are associated with dietary quality, including a substantial overlap between markers associated with the MDS, the E-DII, and the AHEI, especially kynurenines. Unfavorable marker scores, reflecting poorer-quality diets, were associated with increased mortality.
KW - Biomarker
KW - Diet
KW - Dietary pattern
KW - Inflammation
KW - Kynurenine
KW - Mortality
UR - http://www.scopus.com/inward/record.url?scp=85117317146&partnerID=8YFLogxK
U2 - 10.1093/jn/nxab231
DO - 10.1093/jn/nxab231
M3 - Article
C2 - 34320210
AN - SCOPUS:85117317146
SN - 0022-3166
VL - 151
SP - 2908
EP - 2916
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 10
ER -