TY - JOUR
T1 - Inflammatory Cytokines and Lung Cancer Risk in 3 Prospective Studies
AU - Brenner, Darren R.
AU - Fanidi, Anouar
AU - Grankvist, Kjell
AU - Muller, David C.
AU - Brennan, Paul
AU - Manjer, Jonas
AU - Byrnes, Graham
AU - Hodge, Allison
AU - Severi, Gianluca
AU - Giles, Graham G.
AU - Johansson, Mikael
AU - Johansson, Mattias
N1 - Publisher Copyright:
© The Author 2017.
PY - 2017/1/15
Y1 - 2017/1/15
N2 - To further investigate the role of inflammation in lung carcinogenesis, we evaluated associations between proinflammatory cytokines and lung cancer risk. We conducted a case-control study nested within 3 prospective cohort studies-the Melbourne Collaborative Cohort Study (1990-1994), the Malm- Diet and Cancer Study (1991-1996), and the Northern Sweden Health and Disease Study (initiated in 1985)-involving 807 incident lung cancer cases and 807 smoking-matched controls. Conditional logistic regression models adjusting for serum cotinine concentrations were used to estimate odds ratios for lung cancer risk associated with concentrations of interleukin (IL)-1-, IL-2, IL-6, IL-8, IL-10, IL-12, interferon , tumor necrosis factor a, and granulocyte-macrophage colony-stimulating factor. We observed a higher lung cancer risk for participants with elevated concentrations of IL-6 and IL-8. These associations seemed to be stronger among former smokers (for fourth quartile vs. first quartile, odds ratio (OR) = 2.70, 95% confidence interval (CI): 1.55, 4.70) and current smokers (OR = 1.99, 95% CI: 1.15, 3.44) for IL-6 and among former smokers (OR = 2.83, 95% CI: 1.18, 6.75) and current smokers (OR = 1.30, 95% CI: 0.69, 2.44) for IL-8. No notable associations were observed among never smokers. Risk associations with IL-6 and IL-8 were observed for blood samples taken close to diagnosis (<5 years) as well as more than 15 years postdiagnosis.
AB - To further investigate the role of inflammation in lung carcinogenesis, we evaluated associations between proinflammatory cytokines and lung cancer risk. We conducted a case-control study nested within 3 prospective cohort studies-the Melbourne Collaborative Cohort Study (1990-1994), the Malm- Diet and Cancer Study (1991-1996), and the Northern Sweden Health and Disease Study (initiated in 1985)-involving 807 incident lung cancer cases and 807 smoking-matched controls. Conditional logistic regression models adjusting for serum cotinine concentrations were used to estimate odds ratios for lung cancer risk associated with concentrations of interleukin (IL)-1-, IL-2, IL-6, IL-8, IL-10, IL-12, interferon , tumor necrosis factor a, and granulocyte-macrophage colony-stimulating factor. We observed a higher lung cancer risk for participants with elevated concentrations of IL-6 and IL-8. These associations seemed to be stronger among former smokers (for fourth quartile vs. first quartile, odds ratio (OR) = 2.70, 95% confidence interval (CI): 1.55, 4.70) and current smokers (OR = 1.99, 95% CI: 1.15, 3.44) for IL-6 and among former smokers (OR = 2.83, 95% CI: 1.18, 6.75) and current smokers (OR = 1.30, 95% CI: 0.69, 2.44) for IL-8. No notable associations were observed among never smokers. Risk associations with IL-6 and IL-8 were observed for blood samples taken close to diagnosis (<5 years) as well as more than 15 years postdiagnosis.
KW - Cohort studies
KW - Cytokines
KW - Inflammation
KW - Lung neoplasms
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=85021161057&partnerID=8YFLogxK
U2 - 10.1093/aje/kww159
DO - 10.1093/aje/kww159
M3 - Article
C2 - 27998891
AN - SCOPUS:85021161057
SN - 0002-9262
VL - 185
SP - 86
EP - 95
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 2
ER -