Inflammatory potential of diet and pancreatic cancer risk in the EPIC study

Valerie Cayssials; Genevieve Buckland; Marta Crous-Bou; Catalina Bonet; Elisabete Weiderpass; Guri Skie; Dagfinn Aune; Alicia Heath; Therese Haugdahl Nøst; Giovanna Masala; Claudia Agnoli; Maria Santucci De Magistris; Bas Bueno-de-Mesquita; Jeroen Derksen; Inge Huybrechts; Pietro Ferrari; Oscar Franklin; Stina Bodén; Matthias Schulze; Jose Maria Huerta; Aurelio Barricarte; Carlotta Sacerdote; Pilar Amiano; Rosario Tumino; Esther Molina-Montes; Anne Tjønneland; Cecilie Kyrø; Gianluca Severi; Marie Christine Boutron-Ruault; Vinciane Rebours; Verena Katzke; Antonio Agudo; Paula Jakszyn

doi:10.1007/s00394-022-02809-y

Inflammatory potential of diet and pancreatic cancer risk in the EPIC study

Valerie Cayssials, Genevieve Buckland, Marta Crous-Bou, Catalina Bonet, Elisabete Weiderpass, Guri Skie, Dagfinn Aune, Alicia Heath, Therese Haugdahl Nøst, Giovanna Masala, Claudia Agnoli, Maria Santucci De Magistris, Bas Bueno-de-Mesquita, Jeroen Derksen, Inge Huybrechts, Pietro Ferrari, Oscar Franklin, Stina Bodén, Matthias Schulze, Jose Maria HuertaAurelio Barricarte, Carlotta Sacerdote, Pilar Amiano, Rosario Tumino, Esther Molina-Montes, Anne Tjønneland, Cecilie Kyrø, Gianluca Severi, Marie Christine Boutron-Ruault, Vinciane Rebours, Verena Katzke, Antonio Agudo, Paula Jakszyn

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Purpose: There is existing evidence on the potential role of chronic inflammation in the pathogenesis of pancreatic cancer (PC) and on how risk may be modulated by dietary factors. Pro-inflammatory diets are suggested to be associated with increased risk of PC but, so far, evidence remains not conclusive. We examined the association between the dietary inflammatory potential and PC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, which includes 450,112 participants. Methods: After a 14-year follow-up, a total of 1239 incident PC cases were included in this study. The inflammatory potential of the diet was estimated using an Inflammatory Score of the Diet (ISD). Hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between the ISD and PC were estimated using multivariable Cox regression models, adjusted for known risk factors for PC. Results: Participants with higher ISDs had a higher risk of developing PCs. In the fully adjusted multivariate model, the risk of PC increased by 11% (HR 1.11, 95% CI 1.02–1.22) for 1 point each standard deviation increase in the ISD score. Neither obesity nor any other known risk factor for PC showed statistically significant interactions. Conclusion: To the best of our knowledge, this is the first prospective study reporting a positive relationship between the inflammatory potential of diet and PC. Since early diagnosis and treatment of pancreatic cancer might be challenging, prevention remains the major hope for reducing the burden of this disease.

Original language	English
Pages (from-to)	2313-2320
Number of pages	8
Journal	European Journal of Nutrition
Volume	61
Issue number	5
DOIs	https://doi.org/10.1007/s00394-022-02809-y
Publication status	Published - 1 Aug 2022

Keywords

Dietary patterns
Epidemiology
Inflammatory potential of diet
Pancreatic cancer
Prospective cohort

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10.1007/s00394-022-02809-y

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Cayssials, V., Buckland, G., Crous-Bou, M., Bonet, C., Weiderpass, E., Skie, G., Aune, D., Heath, A., Nøst, T. H., Masala, G., Agnoli, C., De Magistris, M. S., Bueno-de-Mesquita, B., Derksen, J., Huybrechts, I., Ferrari, P., Franklin, O., Bodén, S., Schulze, M., ... Jakszyn, P. (2022). Inflammatory potential of diet and pancreatic cancer risk in the EPIC study. European Journal of Nutrition, 61(5), 2313-2320. https://doi.org/10.1007/s00394-022-02809-y

@article{efebc0b45abe4c6a8445e12de32fb408,

title = "Inflammatory potential of diet and pancreatic cancer risk in the EPIC study",

abstract = "Purpose: There is existing evidence on the potential role of chronic inflammation in the pathogenesis of pancreatic cancer (PC) and on how risk may be modulated by dietary factors. Pro-inflammatory diets are suggested to be associated with increased risk of PC but, so far, evidence remains not conclusive. We examined the association between the dietary inflammatory potential and PC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, which includes 450,112 participants. Methods: After a 14-year follow-up, a total of 1239 incident PC cases were included in this study. The inflammatory potential of the diet was estimated using an Inflammatory Score of the Diet (ISD). Hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between the ISD and PC were estimated using multivariable Cox regression models, adjusted for known risk factors for PC. Results: Participants with higher ISDs had a higher risk of developing PCs. In the fully adjusted multivariate model, the risk of PC increased by 11% (HR 1.11, 95% CI 1.02–1.22) for 1 point each standard deviation increase in the ISD score. Neither obesity nor any other known risk factor for PC showed statistically significant interactions. Conclusion: To the best of our knowledge, this is the first prospective study reporting a positive relationship between the inflammatory potential of diet and PC. Since early diagnosis and treatment of pancreatic cancer might be challenging, prevention remains the major hope for reducing the burden of this disease.",

keywords = "Dietary patterns, Epidemiology, Inflammatory potential of diet, Pancreatic cancer, Prospective cohort",

author = "Valerie Cayssials and Genevieve Buckland and Marta Crous-Bou and Catalina Bonet and Elisabete Weiderpass and Guri Skie and Dagfinn Aune and Alicia Heath and N{\o}st, {Therese Haugdahl} and Giovanna Masala and Claudia Agnoli and {De Magistris}, {Maria Santucci} and Bas Bueno-de-Mesquita and Jeroen Derksen and Inge Huybrechts and Pietro Ferrari and Oscar Franklin and Stina Bod{\'e}n and Matthias Schulze and Huerta, {Jose Maria} and Aurelio Barricarte and Carlotta Sacerdote and Pilar Amiano and Rosario Tumino and Esther Molina-Montes and Anne Tj{\o}nneland and Cecilie Kyr{\o} and Gianluca Severi and Boutron-Ruault, {Marie Christine} and Vinciane Rebours and Verena Katzke and Antonio Agudo and Paula Jakszyn",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.",

year = "2022",

month = aug,

day = "1",

doi = "10.1007/s00394-022-02809-y",

language = "English",

volume = "61",

pages = "2313--2320",

journal = "European Journal of Nutrition",

issn = "1436-6207",

number = "5",

}

Cayssials, V, Buckland, G, Crous-Bou, M, Bonet, C, Weiderpass, E, Skie, G, Aune, D, Heath, A, Nøst, TH, Masala, G, Agnoli, C, De Magistris, MS, Bueno-de-Mesquita, B, Derksen, J, Huybrechts, I, Ferrari, P, Franklin, O, Bodén, S, Schulze, M, Huerta, JM, Barricarte, A, Sacerdote, C, Amiano, P, Tumino, R, Molina-Montes, E, Tjønneland, A, Kyrø, C, Severi, G, Boutron-Ruault, MC, Rebours, V, Katzke, V, Agudo, A & Jakszyn, P 2022, 'Inflammatory potential of diet and pancreatic cancer risk in the EPIC study', European Journal of Nutrition, vol. 61, no. 5, pp. 2313-2320. https://doi.org/10.1007/s00394-022-02809-y

TY - JOUR

T1 - Inflammatory potential of diet and pancreatic cancer risk in the EPIC study

AU - Cayssials, Valerie

AU - Buckland, Genevieve

AU - Crous-Bou, Marta

AU - Bonet, Catalina

AU - Weiderpass, Elisabete

AU - Skie, Guri

AU - Aune, Dagfinn

AU - Heath, Alicia

AU - Nøst, Therese Haugdahl

AU - Masala, Giovanna

AU - Agnoli, Claudia

AU - De Magistris, Maria Santucci

AU - Bueno-de-Mesquita, Bas

AU - Derksen, Jeroen

AU - Huybrechts, Inge

AU - Ferrari, Pietro

AU - Franklin, Oscar

AU - Bodén, Stina

AU - Schulze, Matthias

AU - Huerta, Jose Maria

AU - Barricarte, Aurelio

AU - Sacerdote, Carlotta

AU - Amiano, Pilar

AU - Tumino, Rosario

AU - Molina-Montes, Esther

AU - Tjønneland, Anne

AU - Kyrø, Cecilie

AU - Severi, Gianluca

AU - Boutron-Ruault, Marie Christine

AU - Rebours, Vinciane

AU - Katzke, Verena

AU - Agudo, Antonio

AU - Jakszyn, Paula

PY - 2022/8/1

Y1 - 2022/8/1

N2 - Purpose: There is existing evidence on the potential role of chronic inflammation in the pathogenesis of pancreatic cancer (PC) and on how risk may be modulated by dietary factors. Pro-inflammatory diets are suggested to be associated with increased risk of PC but, so far, evidence remains not conclusive. We examined the association between the dietary inflammatory potential and PC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, which includes 450,112 participants. Methods: After a 14-year follow-up, a total of 1239 incident PC cases were included in this study. The inflammatory potential of the diet was estimated using an Inflammatory Score of the Diet (ISD). Hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between the ISD and PC were estimated using multivariable Cox regression models, adjusted for known risk factors for PC. Results: Participants with higher ISDs had a higher risk of developing PCs. In the fully adjusted multivariate model, the risk of PC increased by 11% (HR 1.11, 95% CI 1.02–1.22) for 1 point each standard deviation increase in the ISD score. Neither obesity nor any other known risk factor for PC showed statistically significant interactions. Conclusion: To the best of our knowledge, this is the first prospective study reporting a positive relationship between the inflammatory potential of diet and PC. Since early diagnosis and treatment of pancreatic cancer might be challenging, prevention remains the major hope for reducing the burden of this disease.

AB - Purpose: There is existing evidence on the potential role of chronic inflammation in the pathogenesis of pancreatic cancer (PC) and on how risk may be modulated by dietary factors. Pro-inflammatory diets are suggested to be associated with increased risk of PC but, so far, evidence remains not conclusive. We examined the association between the dietary inflammatory potential and PC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, which includes 450,112 participants. Methods: After a 14-year follow-up, a total of 1239 incident PC cases were included in this study. The inflammatory potential of the diet was estimated using an Inflammatory Score of the Diet (ISD). Hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between the ISD and PC were estimated using multivariable Cox regression models, adjusted for known risk factors for PC. Results: Participants with higher ISDs had a higher risk of developing PCs. In the fully adjusted multivariate model, the risk of PC increased by 11% (HR 1.11, 95% CI 1.02–1.22) for 1 point each standard deviation increase in the ISD score. Neither obesity nor any other known risk factor for PC showed statistically significant interactions. Conclusion: To the best of our knowledge, this is the first prospective study reporting a positive relationship between the inflammatory potential of diet and PC. Since early diagnosis and treatment of pancreatic cancer might be challenging, prevention remains the major hope for reducing the burden of this disease.

KW - Dietary patterns

KW - Epidemiology

KW - Inflammatory potential of diet

KW - Pancreatic cancer

KW - Prospective cohort

UR - http://www.scopus.com/inward/record.url?scp=85123866321&partnerID=8YFLogxK

U2 - 10.1007/s00394-022-02809-y

DO - 10.1007/s00394-022-02809-y

M3 - Article

C2 - 35091827

AN - SCOPUS:85123866321

SN - 1436-6207

VL - 61

SP - 2313

EP - 2320

JO - European Journal of Nutrition

JF - European Journal of Nutrition

IS - 5

ER -

Inflammatory potential of diet and pancreatic cancer risk in the EPIC study

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Keywords

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