Inhibiteurs de ALK de 2e génération dans le cancer bronchique non a petites cellules: revue de la literature

Translated title of the contribution: Second generation ALK inhibitors in non-small cell lung cancer: Systemic review

Marie Viala, Solenn Brosseau, David Planchard, Benjamin Besse, Jean Charles Soria

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

The identification of the EML4-ALK rearrangement in 5% of NSCLC enhanced the development of 1st generation ALK inhibitors such as crizotinib. Two phase III trials demonstrated crizotinib efficacy in second line metastatic (PROFILE 1007) and more recently first line metastatic (PROFILE 1014) NSCLC in terms of progression-free survival and also objective response. However, within 12 to 16 months, patients will progress due to the emergence of acquired resistance mechanisms such as mutation (L1196M) or amplification of the ALK gene, as well as activation of alternative signaling pathways (EGFR, KRAS). Second generation ALK inhibitors have been developed such as ceritinib, alectinib, and AP26113. This review will present those new drugs, summarize the results of their ongoing trials, and discuss the best way to treat ALK+ NSCLC patients.

Translated title of the contributionSecond generation ALK inhibitors in non-small cell lung cancer: Systemic review
Original languageFrench
Pages (from-to)381-389
Number of pages9
JournalBulletin du Cancer
Volume102
Issue number4
DOIs
Publication statusPublished - 1 Apr 2015
Externally publishedYes

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