Inhibiteurs de l'angiogenèse et radiothérapie : du concept à la clinique

Translated title of the contribution: Angiogenesis inhibitors and radiation therapy: From biology to clinical practice

R. Mazeron, D. Azria, E. Deutsch

    Research output: Contribution to journalShort surveypeer-review

    4 Citations (Scopus)

    Abstract

    Angiogenesis is central to cancer research. Recent progresses in understanding its mechanisms have enabled the development of therapies that inhibit this process. Many molecules have shown a synergistic effect in combination with irradiation in preclinical studies, and several are being tested in phase I or II. This effect could be explained by a transient normalization of tumor vasculature, leading to improve tumor oxygenation and thus greater radiosensitivity. Although promising, many questions remain about the dose, optimal sequences of the association.

    Translated title of the contributionAngiogenesis inhibitors and radiation therapy: From biology to clinical practice
    Original languageFrench
    Pages (from-to)568-573
    Number of pages6
    JournalCancer/Radiotherapie
    Volume13
    Issue number6-7
    DOIs
    Publication statusPublished - 1 Oct 2009

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