Abstract
Angiogenesis is central to cancer research. Recent progresses in understanding its mechanisms have enabled the development of therapies that inhibit this process. Many molecules have shown a synergistic effect in combination with irradiation in preclinical studies, and several are being tested in phase I or II. This effect could be explained by a transient normalization of tumor vasculature, leading to improve tumor oxygenation and thus greater radiosensitivity. Although promising, many questions remain about the dose, optimal sequences of the association.
Translated title of the contribution | Angiogenesis inhibitors and radiation therapy: From biology to clinical practice |
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Original language | French |
Pages (from-to) | 568-573 |
Number of pages | 6 |
Journal | Cancer/Radiotherapie |
Volume | 13 |
Issue number | 6-7 |
DOIs | |
Publication status | Published - 1 Oct 2009 |