Interaction méthotrexate-ciprofloxacine: à propos de deux cas d’intoxication sévère

J. H. Dalle; A. Auvrignon; G. Vassal; G. Leverger; C. Kalifa

doi:10.1016/S0929-693X(01)00587-5

Interaction méthotrexate-ciprofloxacine: à propos de deux cas d’intoxication sévère

Translated title of the contribution: Interaction between methotrexate and ciprofloxacin: Report of two cases of severe intoxication

J. H. Dalle, A. Auvrignon, G. Vassal, G. Leverger, C. Kalifa

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Methotrexate elimination may be delayed by different drugs. Such a delay may produce severe toxic complications. Case reports - We report two cases of adolescents treated for malignant diseases who presented a delayed methotrexate elimination even though they received ciprofloxacin. The first patient had already received several courses of methotrexate without toxicity before this episode. The second patient tolerated methotrexate when ciprofloxacin was not associated to the treatment. Conclusion - High-dose methotrexate-ciprofloxacin association should be avoided.

Translated title of the contribution	Interaction between methotrexate and ciprofloxacin: Report of two cases of severe intoxication
Original language	French
Pages (from-to)	1078-1081
Number of pages	4
Journal	Archives de Pediatrie
Volume	8
Issue number	10
DOIs	https://doi.org/10.1016/S0929-693X(01)00587-5
Publication status	Published - 1 Jan 2001

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title = "Interaction m{\'e}thotrexate-ciprofloxacine: {\`a} propos de deux cas d{\textquoteright}intoxication s{\'e}v{\`e}re",

abstract = "Methotrexate elimination may be delayed by different drugs. Such a delay may produce severe toxic complications. Case reports - We report two cases of adolescents treated for malignant diseases who presented a delayed methotrexate elimination even though they received ciprofloxacin. The first patient had already received several courses of methotrexate without toxicity before this episode. The second patient tolerated methotrexate when ciprofloxacin was not associated to the treatment. Conclusion - High-dose methotrexate-ciprofloxacin association should be avoided.",

keywords = "Ciprofloxacin, Methotrexate",

author = "Dalle, {J. H.} and A. Auvrignon and G. Vassal and G. Leverger and C. Kalifa",

year = "2001",

month = jan,

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doi = "10.1016/S0929-693X(01)00587-5",

language = "Fran{\c c}ais",

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journal = "Archives de Pediatrie",

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TY - JOUR

T1 - Interaction méthotrexate-ciprofloxacine

T2 - à propos de deux cas d’intoxication sévère

AU - Dalle, J. H.

AU - Auvrignon, A.

AU - Vassal, G.

AU - Leverger, G.

AU - Kalifa, C.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Methotrexate elimination may be delayed by different drugs. Such a delay may produce severe toxic complications. Case reports - We report two cases of adolescents treated for malignant diseases who presented a delayed methotrexate elimination even though they received ciprofloxacin. The first patient had already received several courses of methotrexate without toxicity before this episode. The second patient tolerated methotrexate when ciprofloxacin was not associated to the treatment. Conclusion - High-dose methotrexate-ciprofloxacin association should be avoided.

AB - Methotrexate elimination may be delayed by different drugs. Such a delay may produce severe toxic complications. Case reports - We report two cases of adolescents treated for malignant diseases who presented a delayed methotrexate elimination even though they received ciprofloxacin. The first patient had already received several courses of methotrexate without toxicity before this episode. The second patient tolerated methotrexate when ciprofloxacin was not associated to the treatment. Conclusion - High-dose methotrexate-ciprofloxacin association should be avoided.

KW - Ciprofloxacin

KW - Methotrexate

UR - http://www.scopus.com/inward/record.url?scp=18144434669&partnerID=8YFLogxK

U2 - 10.1016/S0929-693X(01)00587-5

DO - 10.1016/S0929-693X(01)00587-5

M3 - Article

C2 - 11683100

AN - SCOPUS:18144434669

SN - 0929-693X

VL - 8

SP - 1078

EP - 1081

JO - Archives de Pediatrie

JF - Archives de Pediatrie

IS - 10

ER -

Interaction méthotrexate-ciprofloxacine: à propos de deux cas d’intoxication sévère

Abstract

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