Interferon-γ is produced by another player of innate immune responses: The interferon-producing killer dendritic cell (IKDC)

Mathieu Bonmort; Evelyn Ullrich; Grégoire Mignot; Bénédikt Jacobs; Nathalie Chaput; Laurence Zitvogel

doi:10.1016/j.biochi.2007.04.014

Interferon-γ is produced by another player of innate immune responses: The interferon-producing killer dendritic cell (IKDC)

Mathieu Bonmort, Evelyn Ullrich, Grégoire Mignot, Bénédikt Jacobs, Nathalie Chaput, Laurence Zitvogel

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Interferon-γ is a key cytokine in tumor immunosurveillance. The recently described interferon-producing killer dendritic cell (IKDC), can be distinguished from other innate effectors by its ability to kill a large variety of tumor cells and to produce high amounts of interferon-γ after encountering tumors in the absence of exogenous cytokines. The cytotoxic activity of IKDC was unraveled during an efficient immunotherapy combining c-kit tyrosine kinase inhibitors and interleukin-2, and is mediated through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and interferon type IIR.

Original language	English
Pages (from-to)	872-877
Number of pages	6
Journal	Biochimie
Volume	89
Issue number	6-7
DOIs	https://doi.org/10.1016/j.biochi.2007.04.014
Publication status	Published - 1 Jun 2007

Keywords

Dendritic cells
Imatinib mesylate
Interferon-producing killer dendritic cells
Interferon-γ
Interleukin-2
TNF-related apoptosis-inducing ligand
Tumor immunity
c-kit tyrosine kinase inhibitor

Access to Document

10.1016/j.biochi.2007.04.014

Cite this

@article{6091a67183eb43f3baf6be8aa4e945f0,

title = "Interferon-γ is produced by another player of innate immune responses: The interferon-producing killer dendritic cell (IKDC)",

abstract = "Interferon-γ is a key cytokine in tumor immunosurveillance. The recently described interferon-producing killer dendritic cell (IKDC), can be distinguished from other innate effectors by its ability to kill a large variety of tumor cells and to produce high amounts of interferon-γ after encountering tumors in the absence of exogenous cytokines. The cytotoxic activity of IKDC was unraveled during an efficient immunotherapy combining c-kit tyrosine kinase inhibitors and interleukin-2, and is mediated through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and interferon type IIR.",

keywords = "Dendritic cells, Imatinib mesylate, Interferon-producing killer dendritic cells, Interferon-γ, Interleukin-2, TNF-related apoptosis-inducing ligand, Tumor immunity, c-kit tyrosine kinase inhibitor",

author = "Mathieu Bonmort and Evelyn Ullrich and Gr{\'e}goire Mignot and B{\'e}n{\'e}dikt Jacobs and Nathalie Chaput and Laurence Zitvogel",

note = "Funding Information: M.B. is supported by a Poste d'accueil INSERM, E.U. received a fellowship from the German Forschungsgemeinschaft (DFG), G.M. is supported by the Association pour la Recherche contre le Cancer (ARC). This work has also been supported by EU grants (ALLOSTEM, DC THERA), ARC, and the Ligue Nationale contre le Cancer ({\'e}quipe labellis{\'e}e).",

year = "2007",

month = jun,

day = "1",

doi = "10.1016/j.biochi.2007.04.014",

language = "English",

volume = "89",

pages = "872--877",

journal = "Biochimie",

issn = "0300-9084",

number = "6-7",

}

TY - JOUR

T1 - Interferon-γ is produced by another player of innate immune responses

T2 - The interferon-producing killer dendritic cell (IKDC)

AU - Bonmort, Mathieu

AU - Ullrich, Evelyn

AU - Mignot, Grégoire

AU - Jacobs, Bénédikt

AU - Chaput, Nathalie

AU - Zitvogel, Laurence

N1 - Funding Information: M.B. is supported by a Poste d'accueil INSERM, E.U. received a fellowship from the German Forschungsgemeinschaft (DFG), G.M. is supported by the Association pour la Recherche contre le Cancer (ARC). This work has also been supported by EU grants (ALLOSTEM, DC THERA), ARC, and the Ligue Nationale contre le Cancer (équipe labellisée).

PY - 2007/6/1

Y1 - 2007/6/1

N2 - Interferon-γ is a key cytokine in tumor immunosurveillance. The recently described interferon-producing killer dendritic cell (IKDC), can be distinguished from other innate effectors by its ability to kill a large variety of tumor cells and to produce high amounts of interferon-γ after encountering tumors in the absence of exogenous cytokines. The cytotoxic activity of IKDC was unraveled during an efficient immunotherapy combining c-kit tyrosine kinase inhibitors and interleukin-2, and is mediated through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and interferon type IIR.

AB - Interferon-γ is a key cytokine in tumor immunosurveillance. The recently described interferon-producing killer dendritic cell (IKDC), can be distinguished from other innate effectors by its ability to kill a large variety of tumor cells and to produce high amounts of interferon-γ after encountering tumors in the absence of exogenous cytokines. The cytotoxic activity of IKDC was unraveled during an efficient immunotherapy combining c-kit tyrosine kinase inhibitors and interleukin-2, and is mediated through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and interferon type IIR.

KW - Dendritic cells

KW - Imatinib mesylate

KW - Interferon-producing killer dendritic cells

KW - Interferon-γ

KW - Interleukin-2

KW - TNF-related apoptosis-inducing ligand

KW - Tumor immunity

KW - c-kit tyrosine kinase inhibitor

UR - http://www.scopus.com/inward/record.url?scp=34347220864&partnerID=8YFLogxK

U2 - 10.1016/j.biochi.2007.04.014

DO - 10.1016/j.biochi.2007.04.014

M3 - Article

C2 - 17574720

AN - SCOPUS:34347220864

SN - 0300-9084

VL - 89

SP - 872

EP - 877

JO - Biochimie

JF - Biochimie

IS - 6-7

ER -

Interferon-γ is produced by another player of innate immune responses: The interferon-producing killer dendritic cell (IKDC)

Abstract

Keywords

Access to Document

Other files and links

Cite this