Intricate Links between ER Stress and Apoptosis

Frank Madeo, Guido Kroemer

    Research output: Contribution to journalShort surveypeer-review

    37 Citations (Scopus)

    Abstract

    Bax inhibitor-1 (BI-1) interacts with Bax, neutralizing its proapoptotic activity. In this issue of Molecular Cell, Lisbona et al. (2009) show that BI-1 directly inhibits IRE1α, an essential mediator of the UPR, thereby facilitating crosstalk between apoptosis and ER stress pathways.

    Original languageEnglish
    Pages (from-to)669-670
    Number of pages2
    JournalMolecular Cell
    Volume33
    Issue number6
    DOIs
    Publication statusPublished - 27 Mar 2009

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