Abstract
Bax inhibitor-1 (BI-1) interacts with Bax, neutralizing its proapoptotic activity. In this issue of Molecular Cell, Lisbona et al. (2009) show that BI-1 directly inhibits IRE1α, an essential mediator of the UPR, thereby facilitating crosstalk between apoptosis and ER stress pathways.
Original language | English |
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Pages (from-to) | 669-670 |
Number of pages | 2 |
Journal | Molecular Cell |
Volume | 33 |
Issue number | 6 |
DOIs | |
Publication status | Published - 27 Mar 2009 |