Is earlier better for melanoma checkpoint blockade?

Caroline Robert

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

A neoadjuvant approach relying on the administration of combined anti-CTLA-4–anti-PD-1 treatment before lymph node surgery is evaluated in two phase 1 trials. Encouraging clinical, pathological and immunological responses to neoadjuvant therapy were observed, suggesting that this concept warrants further exploration; however, any future approach must address the unacceptably high toxicity of the regimens evaluated in these trials.

Original languageEnglish
Pages (from-to)1645-1648
Number of pages4
JournalNature Medicine
Volume24
Issue number11
DOIs
Publication statusPublished - 1 Nov 2018
Externally publishedYes

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