TY - JOUR
T1 - Laminin 332 in cancer
T2 - When the extracellular matrix turns signals from cell anchorage to cell movement
AU - Rousselle, Patricia
AU - Scoazec, Jean Yves
N1 - Publisher Copyright:
© 2019 The Authors
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Laminin 332 is crucial in the biology of epithelia. This large extracellular matrix protein consists of the heterotrimeric assembly of three subunits – α3, β3, and γ2 – and its multifunctionality relies on a number of extracellular proteolytic processing events. Laminin 332 is central to normal epithelium homeostasis by sustaining cell adhesion, polarity, proliferation, and differentiation. It also supports a major function in epithelial tissue formation, repair, and regeneration by buttressing cell migration and survival and basement membrane assembly. Interest in this protein increased after the discovery that its expression is perturbed in tumor cells, cancer-associated fibroblasts, and the tumor microenvironment. This review summarizes current knowledge regarding the established involvement of the laminin 332 γ2 chain in tumor invasiveness and discusses the role of its α3 and β3 subunits.
AB - Laminin 332 is crucial in the biology of epithelia. This large extracellular matrix protein consists of the heterotrimeric assembly of three subunits – α3, β3, and γ2 – and its multifunctionality relies on a number of extracellular proteolytic processing events. Laminin 332 is central to normal epithelium homeostasis by sustaining cell adhesion, polarity, proliferation, and differentiation. It also supports a major function in epithelial tissue formation, repair, and regeneration by buttressing cell migration and survival and basement membrane assembly. Interest in this protein increased after the discovery that its expression is perturbed in tumor cells, cancer-associated fibroblasts, and the tumor microenvironment. This review summarizes current knowledge regarding the established involvement of the laminin 332 γ2 chain in tumor invasiveness and discusses the role of its α3 and β3 subunits.
KW - Cancer
KW - Cancer-associated fibroblast
KW - Extracellular matrix
KW - Laminin 332
KW - Microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85074441810&partnerID=8YFLogxK
U2 - 10.1016/j.semcancer.2019.09.026
DO - 10.1016/j.semcancer.2019.09.026
M3 - Review article
C2 - 31639412
AN - SCOPUS:85074441810
SN - 1044-579X
VL - 62
SP - 149
EP - 165
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
ER -