Loss of the TEL/ETV6 gene by a second translocation in ALL patients with t(12;21)

Maryvonne Busson-Le Coniat; H. Élène Poirel; Thierry Leblanc; Olivier A. Bernard; Roland Berger

doi:10.1016/S0145-2126(99)00105-8

Loss of the TEL/ETV6 gene by a second translocation in ALL patients with t(12;21)

Maryvonne Busson-Le Coniat, H. Élène Poirel, Thierry Leblanc, Olivier A. Bernard, Roland Berger

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Inactivation of the non translocated TEL/ETV6 gene is commonly associated with translocation (12;21) of acute lymphoblastic leukemia (ALL). Translocations involving the short arm of chromosome 12 were analysed in two children with t(12;21) ALL. Fluorescence in situ hybridation studies showed that these associated translocations resulted in loss of TEL/ETV6. While hybridization with a YAC probe covering TEL/ETV6 was positive in one patient, analysis with cosmid probes covering the gene demonstrated that the gene was in fact deleted. It is concluded that deletions involving TEL/ETV6 can remain undetected by FISH using only YAC probes.

Original language	English
Pages (from-to)	895-899
Number of pages	5
Journal	Leukemia Research
Volume	23
Issue number	10
DOIs	https://doi.org/10.1016/S0145-2126(99)00105-8
Publication status	Published - 1 Oct 1999
Externally published	Yes

Keywords

Acute lymphoblastic leukemia
ETV6
Gene loss
TEL
Translocation
t(12;21)

Access to Document

10.1016/S0145-2126(99)00105-8

Cite this

@article{7ac4474eaa6b45288513901f470c27f3,

title = "Loss of the TEL/ETV6 gene by a second translocation in ALL patients with t(12;21)",

abstract = "Inactivation of the non translocated TEL/ETV6 gene is commonly associated with translocation (12;21) of acute lymphoblastic leukemia (ALL). Translocations involving the short arm of chromosome 12 were analysed in two children with t(12;21) ALL. Fluorescence in situ hybridation studies showed that these associated translocations resulted in loss of TEL/ETV6. While hybridization with a YAC probe covering TEL/ETV6 was positive in one patient, analysis with cosmid probes covering the gene demonstrated that the gene was in fact deleted. It is concluded that deletions involving TEL/ETV6 can remain undetected by FISH using only YAC probes.",

keywords = "Acute lymphoblastic leukemia, ETV6, Gene loss, TEL, Translocation, t(12;21)",

author = "{Busson-Le Coniat}, Maryvonne and Poirel, {H. {\'E}l{\`e}ne} and Thierry Leblanc and Bernard, {Olivier A.} and Roland Berger",

note = "Funding Information: This work was partly supported by the Ligue Nationale contre le Cancer, l{\textquoteright}ARC. M. Busson Le-Coniat provided the design of the study. H. Poriel and O. Bernard provided critical revision for important intellectual content of the article. T. Leblanc provided study materials. R. Berger drafted the article, provided analysis and data interpretation and gave final approval.",

year = "1999",

month = oct,

day = "1",

doi = "10.1016/S0145-2126(99)00105-8",

language = "English",

volume = "23",

pages = "895--899",

journal = "Leukemia Research",

issn = "0145-2126",

number = "10",

}

TY - JOUR

T1 - Loss of the TEL/ETV6 gene by a second translocation in ALL patients with t(12;21)

AU - Busson-Le Coniat, Maryvonne

AU - Poirel, H. Élène

AU - Leblanc, Thierry

AU - Bernard, Olivier A.

AU - Berger, Roland

N1 - Funding Information: This work was partly supported by the Ligue Nationale contre le Cancer, l’ARC. M. Busson Le-Coniat provided the design of the study. H. Poriel and O. Bernard provided critical revision for important intellectual content of the article. T. Leblanc provided study materials. R. Berger drafted the article, provided analysis and data interpretation and gave final approval.

PY - 1999/10/1

Y1 - 1999/10/1

N2 - Inactivation of the non translocated TEL/ETV6 gene is commonly associated with translocation (12;21) of acute lymphoblastic leukemia (ALL). Translocations involving the short arm of chromosome 12 were analysed in two children with t(12;21) ALL. Fluorescence in situ hybridation studies showed that these associated translocations resulted in loss of TEL/ETV6. While hybridization with a YAC probe covering TEL/ETV6 was positive in one patient, analysis with cosmid probes covering the gene demonstrated that the gene was in fact deleted. It is concluded that deletions involving TEL/ETV6 can remain undetected by FISH using only YAC probes.

AB - Inactivation of the non translocated TEL/ETV6 gene is commonly associated with translocation (12;21) of acute lymphoblastic leukemia (ALL). Translocations involving the short arm of chromosome 12 were analysed in two children with t(12;21) ALL. Fluorescence in situ hybridation studies showed that these associated translocations resulted in loss of TEL/ETV6. While hybridization with a YAC probe covering TEL/ETV6 was positive in one patient, analysis with cosmid probes covering the gene demonstrated that the gene was in fact deleted. It is concluded that deletions involving TEL/ETV6 can remain undetected by FISH using only YAC probes.

KW - Acute lymphoblastic leukemia

KW - ETV6

KW - Gene loss

KW - TEL

KW - Translocation

KW - t(12;21)

UR - http://www.scopus.com/inward/record.url?scp=0032848105&partnerID=8YFLogxK

U2 - 10.1016/S0145-2126(99)00105-8

DO - 10.1016/S0145-2126(99)00105-8

M3 - Article

C2 - 10573134

AN - SCOPUS:0032848105

SN - 0145-2126

VL - 23

SP - 895

EP - 899

JO - Leukemia Research

JF - Leukemia Research

IS - 10

ER -

Loss of the TEL/ETV6 gene by a second translocation in ALL patients with t(12;21)

Abstract

Keywords

Access to Document

Other files and links

Cite this