Mécanismes de carcinogenèse hépatique: quelles pistes pour la radiosensibilisation ?

Translated title of the contribution: New perspectives for radiosensitization in hepatocellular carcinoma: A review of mechanisms involved in liver oncogenesis

C. Chargari, V. Boige, É Deutsch

    Research output: Contribution to journalShort surveypeer-review

    2 Citations (Scopus)

    Abstract

    New perspectives for radiosensitization in hepatocellular carcinoma (HCC) have emerged with the increasing knowledge of mechanisms involved in liver oncogenesis. As a matter of fact, some of these mechanisms have also a role in the response to ionizing radiation. We review some of the major molecular pathways involved in the oncogenesis of hepatocellular carcinoma. These include cellular proliferation patways, repair systems, apoptosis, and angiogenesis. However, there are few preclinical data on concurrent targeted therapies and ionizing radiation in hepatocellular carcinoma models. Preliminary studies are ongoing. Their results might help to better define the potential benefit of such radiosensitizing strategies in the management of hepatocellular carcinoma.

    Translated title of the contributionNew perspectives for radiosensitization in hepatocellular carcinoma: A review of mechanisms involved in liver oncogenesis
    Original languageFrench
    Pages (from-to)32-38
    Number of pages7
    JournalCancer/Radiotherapie
    Volume15
    Issue number1
    DOIs
    Publication statusPublished - 1 Feb 2011

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