Méta-analyses d'essais randomisés sur données individuelles dans le traitement des cancers ORL non métastatiques: Principes, résultats, perspectives

P. Blanchard; J. Bourhis; B. Lacas; G. Le Teuff; S. Michiels; J. P. Pignon

doi:10.1016/j.canrad.2014.12.009

Méta-analyses d'essais randomisés sur données individuelles dans le traitement des cancers ORL non métastatiques: Principes, résultats, perspectives

Translated title of the contribution: Individual patient data meta-analyses of randomized trials for the treatment of non-metastatic head and neck squamous cell carcinomas: Principles, results and perspectives

P. Blanchard, J. Bourhis, B. Lacas, G. Le Teuff, S. Michiels, J. P. Pignon

Research output: Contribution to journal › Short survey › peer-review

2 Citations (Scopus)

Abstract

Meta-analyses are considered as an important pillar of evidence-based medicine. The aim of this review is to describe the main principles of a meta-analysis and to use examples of head and neck oncology to demonstrate their clinical impact and methodological interest. The major role of individual patient data is outlined, as well as the superiority of individual patient data over meta-analyses based on published summary data. The major clinical breakthrough of head and neck meta-analyses are summarized, regarding concomitant chemotherapy, altered fractionated chemotherapy, new regimens of induction chemotherapy or the use of radioprotectants. Recent methodological developments are described, including network meta-analyses, the validation of surrogate markers. Lastly, the future of meta-analyses is discussed in the context of personalized medicine.

Translated title of the contribution	Individual patient data meta-analyses of randomized trials for the treatment of non-metastatic head and neck squamous cell carcinomas: Principles, results and perspectives
Original language	French
Pages (from-to)	198-204
Number of pages	7
Journal	Cancer/Radiotherapie
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/j.canrad.2014.12.009
Publication status	Published - 1 May 2015

Access to Document

10.1016/j.canrad.2014.12.009

Cite this

@article{23e7f291a1c740688f8c6dfc283dda7e,

title = "M{\'e}ta-analyses d'essais randomis{\'e}s sur donn{\'e}es individuelles dans le traitement des cancers ORL non m{\'e}tastatiques: Principes, r{\'e}sultats, perspectives",

abstract = "Meta-analyses are considered as an important pillar of evidence-based medicine. The aim of this review is to describe the main principles of a meta-analysis and to use examples of head and neck oncology to demonstrate their clinical impact and methodological interest. The major role of individual patient data is outlined, as well as the superiority of individual patient data over meta-analyses based on published summary data. The major clinical breakthrough of head and neck meta-analyses are summarized, regarding concomitant chemotherapy, altered fractionated chemotherapy, new regimens of induction chemotherapy or the use of radioprotectants. Recent methodological developments are described, including network meta-analyses, the validation of surrogate markers. Lastly, the future of meta-analyses is discussed in the context of personalized medicine.",

keywords = "Chemotherapy, Head and neck cancer, Individual patient data, Meta-analysis, Network meta-analysis, Radiotherapy, Randomized trials, Surrogate marker",

author = "P. Blanchard and J. Bourhis and B. Lacas and {Le Teuff}, G. and S. Michiels and Pignon, {J. P.}",

note = "Publisher Copyright: {\textcopyright} 2015 Soci{\'e}t{\'e} fran{\c c}aise de radioth{\'e}rapie oncologique (SFRO).",

year = "2015",

month = may,

day = "1",

doi = "10.1016/j.canrad.2014.12.009",

language = "Fran{\c c}ais",

volume = "19",

pages = "198--204",

journal = "Cancer/Radiotherapie",

issn = "1278-3218",

number = "3",

}

TY - JOUR

T1 - Méta-analyses d'essais randomisés sur données individuelles dans le traitement des cancers ORL non métastatiques

T2 - Principes, résultats, perspectives

AU - Blanchard, P.

AU - Bourhis, J.

AU - Lacas, B.

AU - Le Teuff, G.

AU - Michiels, S.

AU - Pignon, J. P.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Meta-analyses are considered as an important pillar of evidence-based medicine. The aim of this review is to describe the main principles of a meta-analysis and to use examples of head and neck oncology to demonstrate their clinical impact and methodological interest. The major role of individual patient data is outlined, as well as the superiority of individual patient data over meta-analyses based on published summary data. The major clinical breakthrough of head and neck meta-analyses are summarized, regarding concomitant chemotherapy, altered fractionated chemotherapy, new regimens of induction chemotherapy or the use of radioprotectants. Recent methodological developments are described, including network meta-analyses, the validation of surrogate markers. Lastly, the future of meta-analyses is discussed in the context of personalized medicine.

AB - Meta-analyses are considered as an important pillar of evidence-based medicine. The aim of this review is to describe the main principles of a meta-analysis and to use examples of head and neck oncology to demonstrate their clinical impact and methodological interest. The major role of individual patient data is outlined, as well as the superiority of individual patient data over meta-analyses based on published summary data. The major clinical breakthrough of head and neck meta-analyses are summarized, regarding concomitant chemotherapy, altered fractionated chemotherapy, new regimens of induction chemotherapy or the use of radioprotectants. Recent methodological developments are described, including network meta-analyses, the validation of surrogate markers. Lastly, the future of meta-analyses is discussed in the context of personalized medicine.

KW - Chemotherapy

KW - Head and neck cancer

KW - Individual patient data

KW - Meta-analysis

KW - Network meta-analysis

KW - Radiotherapy

KW - Randomized trials

KW - Surrogate marker

UR - http://www.scopus.com/inward/record.url?scp=84929508321&partnerID=8YFLogxK

U2 - 10.1016/j.canrad.2014.12.009

DO - 10.1016/j.canrad.2014.12.009

M3 - Brève enquête

C2 - 25858708

AN - SCOPUS:84929508321

SN - 1278-3218

VL - 19

SP - 198

EP - 204

JO - Cancer/Radiotherapie

JF - Cancer/Radiotherapie

IS - 3

ER -

Méta-analyses d'essais randomisés sur données individuelles dans le traitement des cancers ORL non métastatiques: Principes, résultats, perspectives

Abstract

Access to Document

Other files and links

Cite this