Management of melanoma brain metastasis

C. Boutros; C. Robert

doi:10.1007/978-3-030-23417-1_22

Management of melanoma brain metastasis

C. Boutros, C. Robert

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

In the past decades, local therapies including surgery, whole-brain radiation therapy, and stereotactic radiosurgery were considered the pillar of metastatic brain metastasis (MBM) management, although their benefit in terms of overall survival was never demonstrated. Advances in understanding the biology and molecular pathways implicated in melanoma biology and consecutive improvements in metastatic melanoma treatment using anti-BRAF-based targeted therapies for BRAFV600-mutant melanoma as well as immune checkpoint immunotherapy have generated considerable interest in evaluating these novel systemic therapies in treating MBM (Table 22.1).

Original language	English
Title of host publication	Central Nervous System Metastases
Publisher	Springer International Publishing
Pages	281-287
Number of pages	7
ISBN (Electronic)	9783030234171
ISBN (Print)	9783030234164
DOIs	https://doi.org/10.1007/978-3-030-23417-1_22
Publication status	Published - 1 Jan 2019

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AB - In the past decades, local therapies including surgery, whole-brain radiation therapy, and stereotactic radiosurgery were considered the pillar of metastatic brain metastasis (MBM) management, although their benefit in terms of overall survival was never demonstrated. Advances in understanding the biology and molecular pathways implicated in melanoma biology and consecutive improvements in metastatic melanoma treatment using anti-BRAF-based targeted therapies for BRAFV600-mutant melanoma as well as immune checkpoint immunotherapy have generated considerable interest in evaluating these novel systemic therapies in treating MBM (Table 22.1).

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Management of melanoma brain metastasis

Abstract

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