Mechanisms of apoptotic phosphatidylserine exposure

Guillermo Mariño; Guido Kroemer

doi:10.1038/cr.2013.115

Mechanisms of apoptotic phosphatidylserine exposure

Guillermo Mariño, Guido Kroemer

Research output: Contribution to journal › Review article › peer-review

147 Citations (Scopus)

Abstract

It has been a long-standing enigma which scramblase causes phosphatidylserine residues to be exposed on the surface of apoptotic cells, thereby facilitating the phagocytic recognition, engulfment and destruction of apoptotic corpses. In a recent paper in Science, Nagata and coworkers reveal that the scramblases Xkr8 and its C. elegans ortholog, CED-8, are activated by caspase cleavage in apoptotic cells.

Original language	English
Pages (from-to)	1247-1248
Number of pages	2
Journal	Cell Research
Volume	23
Issue number	11
DOIs	https://doi.org/10.1038/cr.2013.115
Publication status	Published - 1 Nov 2013

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10.1038/cr.2013.115

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Mechanisms of apoptotic phosphatidylserine exposure

Abstract

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