Metabolic Control of Longevity

Carlos López-Otín; Lorenzo Galluzzi; José M.P. Freije; Frank Madeo; Guido Kroemer

doi:10.1016/j.cell.2016.07.031

Metabolic Control of Longevity

Carlos López-Otín, Lorenzo Galluzzi, José M.P. Freije, Frank Madeo, Guido Kroemer

Research output: Contribution to journal › Review article › peer-review

574 Citations (Scopus)

Abstract

Several metabolic alterations accumulate over time along with a reduction in biological fitness, suggesting the existence of a “metabolic clock” that controls aging. Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence metabolism. Each of the nine hallmarks of aging is connected to undesirable metabolic alterations. The main features of the “westernized” lifestyle, including hypercaloric nutrition and sedentariness, can accelerate aging as they have detrimental metabolic consequences. Conversely, lifespan-extending maneuvers including caloric restriction impose beneficial pleiotropic effects on metabolism. The introduction of strategies that promote metabolic fitness may extend healthspan in humans.

Original language	English
Pages (from-to)	802-821
Number of pages	20
Journal	Cell
Volume	166
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2016.07.031
Publication status	Published - 11 Aug 2016

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title = "Metabolic Control of Longevity",

abstract = "Several metabolic alterations accumulate over time along with a reduction in biological fitness, suggesting the existence of a “metabolic clock” that controls aging. Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence metabolism. Each of the nine hallmarks of aging is connected to undesirable metabolic alterations. The main features of the “westernized” lifestyle, including hypercaloric nutrition and sedentariness, can accelerate aging as they have detrimental metabolic consequences. Conversely, lifespan-extending maneuvers including caloric restriction impose beneficial pleiotropic effects on metabolism. The introduction of strategies that promote metabolic fitness may extend healthspan in humans.",

author = "Carlos L{\'o}pez-Ot{\'i}n and Lorenzo Galluzzi and Freije, {Jos{\'e} M.P.} and Frank Madeo and Guido Kroemer",

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T1 - Metabolic Control of Longevity

AU - López-Otín, Carlos

AU - Galluzzi, Lorenzo

AU - Freije, José M.P.

AU - Madeo, Frank

AU - Kroemer, Guido

PY - 2016/8/11

Y1 - 2016/8/11

N2 - Several metabolic alterations accumulate over time along with a reduction in biological fitness, suggesting the existence of a “metabolic clock” that controls aging. Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence metabolism. Each of the nine hallmarks of aging is connected to undesirable metabolic alterations. The main features of the “westernized” lifestyle, including hypercaloric nutrition and sedentariness, can accelerate aging as they have detrimental metabolic consequences. Conversely, lifespan-extending maneuvers including caloric restriction impose beneficial pleiotropic effects on metabolism. The introduction of strategies that promote metabolic fitness may extend healthspan in humans.

AB - Several metabolic alterations accumulate over time along with a reduction in biological fitness, suggesting the existence of a “metabolic clock” that controls aging. Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence metabolism. Each of the nine hallmarks of aging is connected to undesirable metabolic alterations. The main features of the “westernized” lifestyle, including hypercaloric nutrition and sedentariness, can accelerate aging as they have detrimental metabolic consequences. Conversely, lifespan-extending maneuvers including caloric restriction impose beneficial pleiotropic effects on metabolism. The introduction of strategies that promote metabolic fitness may extend healthspan in humans.

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U2 - 10.1016/j.cell.2016.07.031

DO - 10.1016/j.cell.2016.07.031

M3 - Review article

C2 - 27518560

AN - SCOPUS:84981312038

SN - 0092-8674

VL - 166

SP - 802

EP - 821

JO - Cell

JF - Cell

IS - 4

ER -

Metabolic Control of Longevity

Abstract

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