Methodologies to increase the level of evidence of real-life proton therapy in head and neck tumors

Francesco Dionisi; Lamberto Widesott; Marco Van Vulpen; Clifton David Fuller; Rocco Frondizi; Marco Meneguzzo; Pierre Blanchard; Maurizio Amichetti; Giuseppe Sanguineti

doi:10.14338/IJPT-20-00051.1

Methodologies to increase the level of evidence of real-life proton therapy in head and neck tumors

Francesco Dionisi, Lamberto Widesott, Marco Van Vulpen, Clifton David Fuller, Rocco Frondizi, Marco Meneguzzo, Pierre Blanchard, Maurizio Amichetti, Giuseppe Sanguineti

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

This review aims to present and assess available and new methodologies to increase the clinical evidence of proton therapy data for patients with head and neck cancer. Despite the increasing number of scientific reports showing the feasibility and effectiveness of proton therapy in head and neck cancer, clinical evidence on the potential benefits of its use remains low for several reasons. In this article, the pros and cons of consolidated and new methodologies in this setting such as randomized clinical trials, the model-based approach, and the use of prospective multicentric registries will be detailed.

Original language	English
Pages (from-to)	328-338
Number of pages	11
Journal	International Journal of Particle Therapy
Volume	8
Issue number	1
DOIs	https://doi.org/10.14338/IJPT-20-00051.1
Publication status	Published - 1 Jun 2021

Keywords

Head and neck cancer
Model-based approach
Proton therapy
Randomized trials
Registries

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abstract = "This review aims to present and assess available and new methodologies to increase the clinical evidence of proton therapy data for patients with head and neck cancer. Despite the increasing number of scientific reports showing the feasibility and effectiveness of proton therapy in head and neck cancer, clinical evidence on the potential benefits of its use remains low for several reasons. In this article, the pros and cons of consolidated and new methodologies in this setting such as randomized clinical trials, the model-based approach, and the use of prospective multicentric registries will be detailed.",

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AU - Dionisi, Francesco

AU - Widesott, Lamberto

AU - Van Vulpen, Marco

AU - Fuller, Clifton David

AU - Frondizi, Rocco

AU - Meneguzzo, Marco

AU - Blanchard, Pierre

AU - Amichetti, Maurizio

AU - Sanguineti, Giuseppe

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AB - This review aims to present and assess available and new methodologies to increase the clinical evidence of proton therapy data for patients with head and neck cancer. Despite the increasing number of scientific reports showing the feasibility and effectiveness of proton therapy in head and neck cancer, clinical evidence on the potential benefits of its use remains low for several reasons. In this article, the pros and cons of consolidated and new methodologies in this setting such as randomized clinical trials, the model-based approach, and the use of prospective multicentric registries will be detailed.

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KW - Model-based approach

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KW - Randomized trials

KW - Registries

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Methodologies to increase the level of evidence of real-life proton therapy in head and neck tumors

Abstract

Keywords

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