Microdosimetry for pulsed e fields in a realistic models of cells and endoplasmic reticulum

Agnese Denzi, Hanna Hanna, Franck M. Andre, Lluis M. Mir, Francesca Apollonio, Micaela Liberti

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Citations (Scopus)

Abstract

Microsecond pulsed electric fields (μsPEFs) with amplitude of tens of kV/m are used to permeabilize the plasma membrane whereas nanosecond pulsed electric fields of MV/m also permeabilize cell internal structures, such as the endoplasmic reticulum. In this work, a numerical realistic model of cell and its reticulum has been realized to study the use of μsPEFs also for the permeabilization of this internal structure.

Original languageEnglish
Title of host publicationSMACD 2017 - 14th International Conference on Synthesis, Modeling, Analysis and Simulation Methods and Applications to Circuit Design
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781509050529
DOIs
Publication statusPublished - 14 Jul 2017
Externally publishedYes
Event14th International Conference on Synthesis, Modeling, Analysis and Simulation Methods and Applications to Circuit Design, SMACD 2017 - Giardini Naxos, Taormina, Italy
Duration: 12 Jun 201715 Jun 2017

Publication series

NameSMACD 2017 - 14th International Conference on Synthesis, Modeling, Analysis and Simulation Methods and Applications to Circuit Design

Conference

Conference14th International Conference on Synthesis, Modeling, Analysis and Simulation Methods and Applications to Circuit Design, SMACD 2017
Country/TerritoryItaly
CityGiardini Naxos, Taormina
Period12/06/1715/06/17

Keywords

  • electropermeabilization
  • electroporation
  • electropulsation
  • endoplamic reticulum
  • mesenchymal stem cells
  • microsecond pulsed electric field

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