Abstract
Whether microglia that reside in different central nervous system niches have distinct functions is unclear. O'Koren and Yu et al. now reveal key functional differences in microglia across two anatomically distinct locations in the retina during homeostasis. Furthermore, in degenerative conditions, microglia migrate to another location where they undergo transcriptional reprogramming and contribute to retinal cytoprotection.
Original language | English |
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Pages (from-to) | 723-737.e7 |
Journal | Immunity |
Volume | 50 |
Issue number | 3 |
DOIs | |
Publication status | Published - 19 Mar 2019 |
Externally published | Yes |
Keywords
- IL-34
- macrophages
- microglia
- microglial heterogeneity
- phagocytes
- retinal degeneration
- retinitis pigmentosa