Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration

Emily G. O'Koren, Chen Yu, Mikael Klingeborn, Alicia Y.W. Wong, Cameron L. Prigge, Rose Mathew, Joan Kalnitsky, Rasha A. Msallam, Aymeric Silvin, Jeremy N. Kay, Catherine Bowes Rickman, Vadim Y. Arshavsky, Florent Ginhoux, Miriam Merad, Daniel R. Saban

Research output: Contribution to journalArticlepeer-review

258 Citations (Scopus)

Abstract

Whether microglia that reside in different central nervous system niches have distinct functions is unclear. O'Koren and Yu et al. now reveal key functional differences in microglia across two anatomically distinct locations in the retina during homeostasis. Furthermore, in degenerative conditions, microglia migrate to another location where they undergo transcriptional reprogramming and contribute to retinal cytoprotection.

Original languageEnglish
Pages (from-to)723-737.e7
JournalImmunity
Volume50
Issue number3
DOIs
Publication statusPublished - 19 Mar 2019
Externally publishedYes

Keywords

  • IL-34
  • macrophages
  • microglia
  • microglial heterogeneity
  • phagocytes
  • retinal degeneration
  • retinitis pigmentosa

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