Migration cues interpretation by clathrin-coated structures

Cell migration is oriented by cues from the environment. Such cues are read and interpreted by the cell and translated into a reorganization of the migration machinery to steer migration. Receptors at the cell surface are central to detect these cues. These receptors can be internalized and this plays an important role in the decision-making process leading to choosing a migration direction. Independently of endocytosis, recent findings suggest that regulation of these receptors and translation of the information they carry into a phenotype is facilitated by their clustering at discrete locations of the plasma membrane. Clathrin-coated structures are archetypal clustering assemblies and thus provide the cell with a finely tunable mechanism for controlling receptor availability. In addition, clathrin-coated structures can be regulated by many factors playing a role in cell migration and thus take part in feedback loop mechanisms that are instrumental in defining a migration direction.