Mise en place de recommandations thérapeutiques pour la prise en charge des neutropénies fébriles chez les enfants atteints de cancer: Expérience du RIFHOP

L. Le Carrer; J. Saulpic; M. Dubrel; M. O. Serinet; H. Pacquement; G. Raimondo; M. D. Tabone; P. Trioche; B. Mesples; J. Furioli; S. Perdereau; H. Seaumes; M. Guillon; C. Guillaumat; A. Chavlon Demersay; B. Chevallier; B. Brethon; C. Ferry; F. Gouraud; M. Belloy; P. Bensaid; C. Dallot; B. Pellegrino; H. Sarda; J. Michon; C. Dufour

doi:10.1016/j.oncohp.2014.07.001

Mise en place de recommandations thérapeutiques pour la prise en charge des neutropénies fébriles chez les enfants atteints de cancer: Expérience du RIFHOP

Translated title of the contribution: Clinical practice guideline for the use of antimicrobial agents in neutropenic children with cancer: Experience of the RIFHOP

L. Le Carrer, J. Saulpic, M. Dubrel, M. O. Serinet, H. Pacquement, G. Raimondo, M. D. Tabone, P. Trioche, B. Mesples, J. Furioli, S. Perdereau, H. Seaumes, M. Guillon, C. Guillaumat, A. Chavlon Demersay, B. Chevallier, B. Brethon, C. Ferry, F. Gouraud, M. BelloyP. Bensaid, C. Dallot, B. Pellegrino, H. Sarda, J. Michon, C. Dufour

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Abstract

Purpose. - To evaluate the implementation of clinical guideline for the use of antimicrobial agents in febrile neutropenia in the Île-de-France Network of Pediatric Hematology-Oncology (RIFHOP) and the incidence of documented infections in febrile neutropenia. Patients and methods. - Prospective observational multicenter study in children treated for solid tumors or hematologic malignancies with febrile neutropenia after conventional chemotherapy in Pediatric unit of RIFHOP over a period of 6 months. Results. - One hundred and seventy-six febrile neutropenia occurred in 144 children (77 malignancies - 67 solid tumors). Guideline for first-line antimicrobial treatment was followed in 91% of cases. Antimicrobial treatment has been adapted according to the guidelines of RIFHOP in 88% of cases and the recommendations for the management of outpatients were observed in 87 % of febrile neutropenia. Microbiological documentation was found in 33.5% with a prevalence of urinary tract infection (Escherichia coli). Conclusions. - The feasibility and effectiveness of these guidelines seem to be excellent with an incidence of documented infection comparable to the literature.

Translated title of the contribution	Clinical practice guideline for the use of antimicrobial agents in neutropenic children with cancer: Experience of the RIFHOP
Original language	French
Pages (from-to)	132-140
Number of pages	9
Journal	Revue d'Oncologie Hematologie Pediatrique
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/j.oncohp.2014.07.001
Publication status	Published - 1 Sept 2014

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Le Carrer, L., Saulpic, J., Dubrel, M., Serinet, M. O., Pacquement, H., Raimondo, G., Tabone, M. D., Trioche, P., Mesples, B., Furioli, J., Perdereau, S., Seaumes, H., Guillon, M., Guillaumat, C., Chavlon Demersay, A., Chevallier, B., Brethon, B., Ferry, C., Gouraud, F., ... Dufour, C. (2014). Mise en place de recommandations thérapeutiques pour la prise en charge des neutropénies fébriles chez les enfants atteints de cancer: Expérience du RIFHOP. Revue d'Oncologie Hematologie Pediatrique, 2(3), 132-140. https://doi.org/10.1016/j.oncohp.2014.07.001

@article{b2cfc565549f4249855fc77349ac2f76,

title = "Mise en place de recommandations th{\'e}rapeutiques pour la prise en charge des neutrop{\'e}nies f{\'e}briles chez les enfants atteints de cancer: Exp{\'e}rience du RIFHOP",

abstract = "Purpose. - To evaluate the implementation of clinical guideline for the use of antimicrobial agents in febrile neutropenia in the {\^I}le-de-France Network of Pediatric Hematology-Oncology (RIFHOP) and the incidence of documented infections in febrile neutropenia. Patients and methods. - Prospective observational multicenter study in children treated for solid tumors or hematologic malignancies with febrile neutropenia after conventional chemotherapy in Pediatric unit of RIFHOP over a period of 6 months. Results. - One hundred and seventy-six febrile neutropenia occurred in 144 children (77 malignancies - 67 solid tumors). Guideline for first-line antimicrobial treatment was followed in 91% of cases. Antimicrobial treatment has been adapted according to the guidelines of RIFHOP in 88% of cases and the recommendations for the management of outpatients were observed in 87 % of febrile neutropenia. Microbiological documentation was found in 33.5% with a prevalence of urinary tract infection (Escherichia coli). Conclusions. - The feasibility and effectiveness of these guidelines seem to be excellent with an incidence of documented infection comparable to the literature.",

keywords = "Antimicrobial agents, Cancer, Childhood, Neutropenia",

author = "{Le Carrer}, L. and J. Saulpic and M. Dubrel and Serinet, {M. O.} and H. Pacquement and G. Raimondo and Tabone, {M. D.} and P. Trioche and B. Mesples and J. Furioli and S. Perdereau and H. Seaumes and M. Guillon and C. Guillaumat and {Chavlon Demersay}, A. and B. Chevallier and B. Brethon and C. Ferry and F. Gouraud and M. Belloy and P. Bensaid and C. Dallot and B. Pellegrino and H. Sarda and J. Michon and C. Dufour",

note = "Publisher Copyright: {\textcopyright} 2014 Published by Elsevier Masson SAS.",

year = "2014",

month = sep,

day = "1",

doi = "10.1016/j.oncohp.2014.07.001",

language = "Fran{\c c}ais",

volume = "2",

pages = "132--140",

journal = "Revue d'Oncologie Hematologie Pediatrique",

issn = "2213-4670",

number = "3",

}

Le Carrer, L, Saulpic, J, Dubrel, M, Serinet, MO, Pacquement, H, Raimondo, G, Tabone, MD, Trioche, P, Mesples, B, Furioli, J, Perdereau, S, Seaumes, H, Guillon, M, Guillaumat, C, Chavlon Demersay, A, Chevallier, B, Brethon, B, Ferry, C, Gouraud, F, Belloy, M, Bensaid, P, Dallot, C, Pellegrino, B, Sarda, H, Michon, J & Dufour, C 2014, 'Mise en place de recommandations thérapeutiques pour la prise en charge des neutropénies fébriles chez les enfants atteints de cancer: Expérience du RIFHOP', Revue d'Oncologie Hematologie Pediatrique, vol. 2, no. 3, pp. 132-140. https://doi.org/10.1016/j.oncohp.2014.07.001

TY - JOUR

T1 - Mise en place de recommandations thérapeutiques pour la prise en charge des neutropénies fébriles chez les enfants atteints de cancer

T2 - Expérience du RIFHOP

AU - Le Carrer, L.

AU - Saulpic, J.

AU - Dubrel, M.

AU - Serinet, M. O.

AU - Pacquement, H.

AU - Raimondo, G.

AU - Tabone, M. D.

AU - Trioche, P.

AU - Mesples, B.

AU - Furioli, J.

AU - Perdereau, S.

AU - Seaumes, H.

AU - Guillon, M.

AU - Guillaumat, C.

AU - Chavlon Demersay, A.

AU - Chevallier, B.

AU - Brethon, B.

AU - Ferry, C.

AU - Gouraud, F.

AU - Belloy, M.

AU - Bensaid, P.

AU - Dallot, C.

AU - Pellegrino, B.

AU - Sarda, H.

AU - Michon, J.

AU - Dufour, C.

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Purpose. - To evaluate the implementation of clinical guideline for the use of antimicrobial agents in febrile neutropenia in the Île-de-France Network of Pediatric Hematology-Oncology (RIFHOP) and the incidence of documented infections in febrile neutropenia. Patients and methods. - Prospective observational multicenter study in children treated for solid tumors or hematologic malignancies with febrile neutropenia after conventional chemotherapy in Pediatric unit of RIFHOP over a period of 6 months. Results. - One hundred and seventy-six febrile neutropenia occurred in 144 children (77 malignancies - 67 solid tumors). Guideline for first-line antimicrobial treatment was followed in 91% of cases. Antimicrobial treatment has been adapted according to the guidelines of RIFHOP in 88% of cases and the recommendations for the management of outpatients were observed in 87 % of febrile neutropenia. Microbiological documentation was found in 33.5% with a prevalence of urinary tract infection (Escherichia coli). Conclusions. - The feasibility and effectiveness of these guidelines seem to be excellent with an incidence of documented infection comparable to the literature.

AB - Purpose. - To evaluate the implementation of clinical guideline for the use of antimicrobial agents in febrile neutropenia in the Île-de-France Network of Pediatric Hematology-Oncology (RIFHOP) and the incidence of documented infections in febrile neutropenia. Patients and methods. - Prospective observational multicenter study in children treated for solid tumors or hematologic malignancies with febrile neutropenia after conventional chemotherapy in Pediatric unit of RIFHOP over a period of 6 months. Results. - One hundred and seventy-six febrile neutropenia occurred in 144 children (77 malignancies - 67 solid tumors). Guideline for first-line antimicrobial treatment was followed in 91% of cases. Antimicrobial treatment has been adapted according to the guidelines of RIFHOP in 88% of cases and the recommendations for the management of outpatients were observed in 87 % of febrile neutropenia. Microbiological documentation was found in 33.5% with a prevalence of urinary tract infection (Escherichia coli). Conclusions. - The feasibility and effectiveness of these guidelines seem to be excellent with an incidence of documented infection comparable to the literature.

KW - Antimicrobial agents

KW - Cancer

KW - Childhood

KW - Neutropenia

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U2 - 10.1016/j.oncohp.2014.07.001

DO - 10.1016/j.oncohp.2014.07.001

M3 - Article

AN - SCOPUS:85018820657

SN - 2213-4670

VL - 2

SP - 132

EP - 140

JO - Revue d'Oncologie Hematologie Pediatrique

JF - Revue d'Oncologie Hematologie Pediatrique

IS - 3

ER -

Mise en place de recommandations thérapeutiques pour la prise en charge des neutropénies fébriles chez les enfants atteints de cancer: Expérience du RIFHOP

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