Mitochondrial control of apoptosis

Guido Kroemer; Naoufal Zamzami; Santos A. Susin

doi:10.1016/S0167-5699(97)80014-X

Mitochondrial control of apoptosis

Guido Kroemer, Naoufal Zamzami, Santos A. Susin

Research output: Contribution to journal › Review article › peer-review

1396 Citations (Scopus)

Abstract

The apoptotic process can be subdivided into three phases: a death-stimulus-dependent, heterogeneous induction phase, a common effector phase during which the 'decision to die' is taken, and a common degradation phase during which cells acquire the biochemical and morphological features of end-stage apoptosis. Here, Guido Kroemer, Naoufal Zamzami and Santos Susin discuss the implication of mitochondrial events in the apoptotic effector phase.

Original language	English
Pages (from-to)	44-51
Number of pages	8
Journal	Immunology Today
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/S0167-5699(97)80014-X
Publication status	Published - 1 Jan 1997
Externally published	Yes

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10.1016/S0167-5699(97)80014-X

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title = "Mitochondrial control of apoptosis",

abstract = "The apoptotic process can be subdivided into three phases: a death-stimulus-dependent, heterogeneous induction phase, a common effector phase during which the 'decision to die' is taken, and a common degradation phase during which cells acquire the biochemical and morphological features of end-stage apoptosis. Here, Guido Kroemer, Naoufal Zamzami and Santos Susin discuss the implication of mitochondrial events in the apoptotic effector phase.",

author = "Guido Kroemer and Naoufal Zamzami and Susin, {Santos A.}",

note = "Funding Information: We thank J.C. Ameisen, M. Castedo, A. Macho and E Marchetti for allowing us to quote their unpublished work. This work was supported by ARC, ANRS, CNRS, FRM, INSERM, Leo Foundation, Ligue contre le Cancer, NATO and PICASSOp rogram.",

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AU - Kroemer, Guido

AU - Zamzami, Naoufal

AU - Susin, Santos A.

N1 - Funding Information: We thank J.C. Ameisen, M. Castedo, A. Macho and E Marchetti for allowing us to quote their unpublished work. This work was supported by ARC, ANRS, CNRS, FRM, INSERM, Leo Foundation, Ligue contre le Cancer, NATO and PICASSOp rogram.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - The apoptotic process can be subdivided into three phases: a death-stimulus-dependent, heterogeneous induction phase, a common effector phase during which the 'decision to die' is taken, and a common degradation phase during which cells acquire the biochemical and morphological features of end-stage apoptosis. Here, Guido Kroemer, Naoufal Zamzami and Santos Susin discuss the implication of mitochondrial events in the apoptotic effector phase.

AB - The apoptotic process can be subdivided into three phases: a death-stimulus-dependent, heterogeneous induction phase, a common effector phase during which the 'decision to die' is taken, and a common degradation phase during which cells acquire the biochemical and morphological features of end-stage apoptosis. Here, Guido Kroemer, Naoufal Zamzami and Santos Susin discuss the implication of mitochondrial events in the apoptotic effector phase.

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DO - 10.1016/S0167-5699(97)80014-X

M3 - Review article

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VL - 18

SP - 44

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JO - Immunology Today

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Mitochondrial control of apoptosis

Abstract

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