Mitochondrial control of apoptosis: An introduction

Guido Kroemer

doi:10.1016/S0006-291X(03)00614-4

Mitochondrial control of apoptosis: An introduction

Guido Kroemer

Research output: Contribution to journal › Article › peer-review

273 Citations (Scopus)

Abstract

Mitochondrial membrane permeabilization [MMP] constitutes an essential step of the intrinsic pathway leading to apoptosis. Several oncoproteins, tumor suppressor gene products, viral virulence factors and pharmacological agents modulate apoptosis via direct effects on mitochondria. This has far-reaching implications for the pathophysiology of several major diseases such as cancer, neurodegeneration, and AIDS. The detailed investigation of the mechanisms of MMP will hopefully lead to the discovery of suitable drug targets for therapeutic intervention on cell death control.

Original language	English
Pages (from-to)	433-435
Number of pages	3
Journal	Biochemical and Biophysical Research Communications
Volume	304
Issue number	3
DOIs	https://doi.org/10.1016/S0006-291X(03)00614-4
Publication status	Published - 9 May 2003
Externally published	Yes

Keywords

Bcl-2
Cancer
Necrosis
Neurodegeneration
Programmed cell death

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10.1016/S0006-291X(03)00614-4

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abstract = "Mitochondrial membrane permeabilization [MMP] constitutes an essential step of the intrinsic pathway leading to apoptosis. Several oncoproteins, tumor suppressor gene products, viral virulence factors and pharmacological agents modulate apoptosis via direct effects on mitochondria. This has far-reaching implications for the pathophysiology of several major diseases such as cancer, neurodegeneration, and AIDS. The detailed investigation of the mechanisms of MMP will hopefully lead to the discovery of suitable drug targets for therapeutic intervention on cell death control.",

keywords = "Bcl-2, Cancer, Necrosis, Neurodegeneration, Programmed cell death",

author = "Guido Kroemer",

note = "Funding Information: The author{\textquoteright}s own work is supported by a special grant from the Ligue Nationale contre le Cancer, as well as by grants from ANRS, and the European Commission (QLG1-CT-1999-00739).",

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T2 - An introduction

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Y1 - 2003/5/9

N2 - Mitochondrial membrane permeabilization [MMP] constitutes an essential step of the intrinsic pathway leading to apoptosis. Several oncoproteins, tumor suppressor gene products, viral virulence factors and pharmacological agents modulate apoptosis via direct effects on mitochondria. This has far-reaching implications for the pathophysiology of several major diseases such as cancer, neurodegeneration, and AIDS. The detailed investigation of the mechanisms of MMP will hopefully lead to the discovery of suitable drug targets for therapeutic intervention on cell death control.

AB - Mitochondrial membrane permeabilization [MMP] constitutes an essential step of the intrinsic pathway leading to apoptosis. Several oncoproteins, tumor suppressor gene products, viral virulence factors and pharmacological agents modulate apoptosis via direct effects on mitochondria. This has far-reaching implications for the pathophysiology of several major diseases such as cancer, neurodegeneration, and AIDS. The detailed investigation of the mechanisms of MMP will hopefully lead to the discovery of suitable drug targets for therapeutic intervention on cell death control.

KW - Bcl-2

KW - Cancer

KW - Necrosis

KW - Neurodegeneration

KW - Programmed cell death

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U2 - 10.1016/S0006-291X(03)00614-4

DO - 10.1016/S0006-291X(03)00614-4

M3 - Article

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SN - 0006-291X

VL - 304

SP - 433

EP - 435

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Mitochondrial control of apoptosis: An introduction

Abstract

Keywords

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