Mitochondrial control of cell death

Guido Kroemer, John C. Reed

    Research output: Contribution to journalReview articlepeer-review

    2855 Citations (Scopus)

    Abstract

    In many instances, permeabilization of mitochondrial membranes is a rate-limiting step of apoptotic or necrotic cell demise. This has important consequences for the pathophysiology of cell death, as well as for its pharmacological control.

    Original languageEnglish
    Pages (from-to)513-519
    Number of pages7
    JournalNature Medicine
    Volume6
    Issue number5
    DOIs
    Publication statusPublished - 1 May 2000

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