Mitotic catastrophe: a mechanism for avoiding genomic instability.

Ilio Vitale; Lorenzo Galluzzi; Maria Castedo; Guido Kroemer

doi:10.1038/nrm3115

Mitotic catastrophe: a mechanism for avoiding genomic instability.

Ilio Vitale, Lorenzo Galluzzi, Maria Castedo, Guido Kroemer

Research output: Contribution to journal › Article › peer-review

692 Citations (Scopus)

Abstract

The improper distribution of chromosomes during mitosis compromises cellular functions and can reduce cellular fitness or contribute to malignant transformation. As a countermeasure, higher eukaryotes have developed strategies for eliminating mitosis-incompetent cells, one of which is mitotic catastrophe. Mitotic catastrophe is driven by a complex and poorly understood signalling cascade but, from a functional perspective, it can be defined as an oncosuppressive mechanism that precedes (and is distinct from) apoptosis, necrosis or senescence. Accordingly, the disruption of mitotic catastrophe precipitates tumorigenesis and cancer progression, and its induction constitutes a therapeutic endpoint.

Original language	English
Pages (from-to)	385-392
Number of pages	8
Journal	Nature Reviews Molecular Cell Biology
Volume	12
Issue number	6
DOIs	https://doi.org/10.1038/nrm3115
Publication status	Published - 1 Jun 2011

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Mitotic catastrophe: a mechanism for avoiding genomic instability.

Abstract

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