Model predicting the ypN0 status after good response to chemoradiotherapy in rectal cancer

F. Dumont, P. Dartigues, B. Delga, E. Thibaudeau, L. Benhaim, L. Campion, J. F. Mosnier, J. Raimbourg, O. Kerdraon, D. Goéré

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    Abstract

    Background: The purpose of this study was to identify the predictive factors for ypN0 status in tumors with good pathologic response to chemoradiotherapy (CRT). Methods: A retrospective chart review was conducted on patients at two tertiary cancer center who underwent rectal resection after good response to CRT between 2000 and 2013. Results: No preoperative treatment (oxaliplatin use, radiotherapy boost of 5,4 Gy, delay CRT-surgery) impacted on the ypN status. In the multivariate analysis, only a ypT<3 (HR 7.5 [2,9–19.5]) was significant and no lymphovascular invasion (HR 8,9 [1.6–49.8]) was limited to significance.The best model predicting the ypN0 status used only the ypT status<3. The major part (92.2%) of patients with ypT0-2 tumors had no LN invasion. Conclusion: The risk of lymph node involvement metastases was only 7.8% for the patients with an ypT0-2 status. A fullthickness transanal resection coud be the futur treatment of these patients.

    Original languageEnglish
    Pages (from-to)438-443
    Number of pages6
    JournalAmerican Journal of Surgery
    Volume216
    Issue number3
    DOIs
    Publication statusPublished - 1 Sept 2018

    Keywords

    • Chemoradiotherapy
    • Chemoradiotherapy T status
    • Good response
    • Lymph node
    • Nodal staging
    • Rectal cancer

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