Abstract
Background: The purpose of this study was to identify the predictive factors for ypN0 status in tumors with good pathologic response to chemoradiotherapy (CRT). Methods: A retrospective chart review was conducted on patients at two tertiary cancer center who underwent rectal resection after good response to CRT between 2000 and 2013. Results: No preoperative treatment (oxaliplatin use, radiotherapy boost of 5,4 Gy, delay CRT-surgery) impacted on the ypN status. In the multivariate analysis, only a ypT<3 (HR 7.5 [2,9–19.5]) was significant and no lymphovascular invasion (HR 8,9 [1.6–49.8]) was limited to significance.The best model predicting the ypN0 status used only the ypT status<3. The major part (92.2%) of patients with ypT0-2 tumors had no LN invasion. Conclusion: The risk of lymph node involvement metastases was only 7.8% for the patients with an ypT0-2 status. A fullthickness transanal resection coud be the futur treatment of these patients.
Original language | English |
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Pages (from-to) | 438-443 |
Number of pages | 6 |
Journal | American Journal of Surgery |
Volume | 216 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Sept 2018 |
Keywords
- Chemoradiotherapy
- Chemoradiotherapy T status
- Good response
- Lymph node
- Nodal staging
- Rectal cancer