Monitoring SPB biogenesis in fission yeast with high resolution and quantitative fluorescent microscopy

Imene B. Bouhlel, Kathleen Scheffler, Phong T. Tran, Anne Paoletti

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Like centrosomes, yeast spindle pole bodies (SPBs) undergo a tightly controlled duplication cycle in order to restrict their number to one or two per cell and promote the assembly of a bipolar spindle at mitotic entry. This conservative duplication cycle is tightly coordinated with cell cycle progression although the mechanisms that ensure this coordination remain largely unknown. In this chapter, we describe simple high resolution microscopy- and quantitative light microscopy-based methods that allow to monitor SPB biogenesis in fission yeast and may be useful to study the molecular pathways controlling the successive phases of the duplication cycle.

Original languageEnglish
Title of host publicationMethods in Cell Biology
Subtitle of host publicationCentrosome
EditorsKaren Oegema, Renata Basto
PublisherAcademic Press Inc.
Pages383-392
Number of pages10
ISBN (Print)9780128024492
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Publication series

NameMethods in Cell Biology
Volume129
ISSN (Print)0091-679X

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