MOZ/TIF2-induced acute myeloid leukaemia in transgenic fish

Julia Zhuravleva; Jérôme Paggetti; Laurent Martin; Arlette Hammann; Eric Solary; Jean Noël Bastie; Laurent Delva

doi:10.1111/j.1365-2141.2008.07362.x

MOZ/TIF2-induced acute myeloid leukaemia in transgenic fish

Julia Zhuravleva, Jérôme Paggetti, Laurent Martin, Arlette Hammann, Eric Solary, Jean Noël Bastie, Laurent Delva

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

The inv(8)(p11q13) chromosomal abnormality, described in acute myeloid leukaemias (AML), fuses the histone acetyl-transferase (HAT) MYST3 (MOZ) gene with another HAT gene, NCOA2 (TIF2). We generated a transgenic zebrafish in which the MYST3//NCOA2 fusion gene was expressed under control of the spi1 promoter. An AML developed in 2 of 180 MYST3/NCOA2-EGFP-expressing embryos, 14 and 26 months after injection of the fusion gene in a one-cell embryo, respectively. This leukaemia was characterised by an extensive invasion of kidneys by myeloid blast cells. This model, which is the first zebrafish model of AML, demonstrates the oncogenic potency of MYST3/NCOA2 fusion gene.

Original language	English
Pages (from-to)	378-382
Number of pages	5
Journal	British Journal of Haematology
Volume	143
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2141.2008.07362.x
Publication status	Published - 1 Nov 2008
Externally published	Yes

Keywords

Acute myeloid leukaemia
Animal model
Histone acetyl-transferase
MYST3/NCOA2
Zebrafish

Access to Document

10.1111/j.1365-2141.2008.07362.x

Cite this

@article{0ebaf7e063634918a3ef39a98a1fbbdb,

title = "MOZ/TIF2-induced acute myeloid leukaemia in transgenic fish",

abstract = "The inv(8)(p11q13) chromosomal abnormality, described in acute myeloid leukaemias (AML), fuses the histone acetyl-transferase (HAT) MYST3 (MOZ) gene with another HAT gene, NCOA2 (TIF2). We generated a transgenic zebrafish in which the MYST3//NCOA2 fusion gene was expressed under control of the spi1 promoter. An AML developed in 2 of 180 MYST3/NCOA2-EGFP-expressing embryos, 14 and 26 months after injection of the fusion gene in a one-cell embryo, respectively. This leukaemia was characterised by an extensive invasion of kidneys by myeloid blast cells. This model, which is the first zebrafish model of AML, demonstrates the oncogenic potency of MYST3/NCOA2 fusion gene.",

keywords = "Acute myeloid leukaemia, Animal model, Histone acetyl-transferase, MYST3/NCOA2, Zebrafish",

author = "Julia Zhuravleva and J{\'e}r{\^o}me Paggetti and Laurent Martin and Arlette Hammann and Eric Solary and Bastie, {Jean No{\"e}l} and Laurent Delva",

year = "2008",

month = nov,

day = "1",

doi = "10.1111/j.1365-2141.2008.07362.x",

language = "English",

volume = "143",

pages = "378--382",

journal = "British Journal of Haematology",

issn = "0007-1048",

number = "3",

}

TY - JOUR

T1 - MOZ/TIF2-induced acute myeloid leukaemia in transgenic fish

AU - Zhuravleva, Julia

AU - Paggetti, Jérôme

AU - Martin, Laurent

AU - Hammann, Arlette

AU - Solary, Eric

AU - Bastie, Jean Noël

AU - Delva, Laurent

PY - 2008/11/1

Y1 - 2008/11/1

N2 - The inv(8)(p11q13) chromosomal abnormality, described in acute myeloid leukaemias (AML), fuses the histone acetyl-transferase (HAT) MYST3 (MOZ) gene with another HAT gene, NCOA2 (TIF2). We generated a transgenic zebrafish in which the MYST3//NCOA2 fusion gene was expressed under control of the spi1 promoter. An AML developed in 2 of 180 MYST3/NCOA2-EGFP-expressing embryos, 14 and 26 months after injection of the fusion gene in a one-cell embryo, respectively. This leukaemia was characterised by an extensive invasion of kidneys by myeloid blast cells. This model, which is the first zebrafish model of AML, demonstrates the oncogenic potency of MYST3/NCOA2 fusion gene.

AB - The inv(8)(p11q13) chromosomal abnormality, described in acute myeloid leukaemias (AML), fuses the histone acetyl-transferase (HAT) MYST3 (MOZ) gene with another HAT gene, NCOA2 (TIF2). We generated a transgenic zebrafish in which the MYST3//NCOA2 fusion gene was expressed under control of the spi1 promoter. An AML developed in 2 of 180 MYST3/NCOA2-EGFP-expressing embryos, 14 and 26 months after injection of the fusion gene in a one-cell embryo, respectively. This leukaemia was characterised by an extensive invasion of kidneys by myeloid blast cells. This model, which is the first zebrafish model of AML, demonstrates the oncogenic potency of MYST3/NCOA2 fusion gene.

KW - Acute myeloid leukaemia

KW - Animal model

KW - Histone acetyl-transferase

KW - MYST3/NCOA2

KW - Zebrafish

UR - http://www.scopus.com/inward/record.url?scp=54049083125&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2141.2008.07362.x

DO - 10.1111/j.1365-2141.2008.07362.x

M3 - Article

C2 - 18729850

AN - SCOPUS:54049083125

SN - 0007-1048

VL - 143

SP - 378

EP - 382

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 3

ER -

MOZ/TIF2-induced acute myeloid leukaemia in transgenic fish

Abstract

Keywords

Access to Document

Other files and links

Cite this