TY - JOUR
T1 - Multimodal treatment and long-term outcome of patients with esthesioneuroblastoma
AU - Modesto, A.
AU - Blanchard, P.
AU - Tao, Y. G.
AU - Rives, M.
AU - Janot, F.
AU - Serrano, E.
AU - Benlyazid, A.
AU - Guigay, J.
AU - Ferrand, F. R.
AU - Delord, J. P.
AU - Bourhis, J.
AU - Daly-Schveitzer, N.
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Purpose/objectives To analyze the clinical features, treatment modalities and outcome of patients treated for a localized esthesioneuroblastoma (ENB). Materials and methods Forty-three consecutive patients with biopsy proven ENB treated at two referral cancer centers between 1998 and 2010 were retrospectively reviewed. Results Overall, 5 patients had stage A disease, 13 stage B, 16 stage C and 9 stage D according to the modified Kadish classification. Neo-adjuvant chemotherapy was performed in 23 patients leading to a 74 % response rate. Thirty-one patients were treated by surgery. Thirty-nine patients (90.6%) underwent radiation therapy. Twelve patients received bilateral cervical lymph node irradiation (LNI). After a median follow-up of 77 months, the 5-year overall and progression free survival were 65% and 57%. Twelve patients (28%) had a locoregional relapse leading to 10 ENB-related deaths. The major prognostic factor was the modified Kadish stage with a 3-year survival for stage A-B, C and D of 100%, 48% and 22% respectively (p < 0.0001). Two (9%) isolated cervical lymph node relapses occurred among staged B and C patients treated without elective LNI and none after elective or adjuvant LNI. Conclusion The high risk of locoregional failure in ENB justifies the use of multimodal therapy. Induction chemotherapy leads to a high response rate. Elective LNI might prevent regional failure in locally advanced disease.
AB - Purpose/objectives To analyze the clinical features, treatment modalities and outcome of patients treated for a localized esthesioneuroblastoma (ENB). Materials and methods Forty-three consecutive patients with biopsy proven ENB treated at two referral cancer centers between 1998 and 2010 were retrospectively reviewed. Results Overall, 5 patients had stage A disease, 13 stage B, 16 stage C and 9 stage D according to the modified Kadish classification. Neo-adjuvant chemotherapy was performed in 23 patients leading to a 74 % response rate. Thirty-one patients were treated by surgery. Thirty-nine patients (90.6%) underwent radiation therapy. Twelve patients received bilateral cervical lymph node irradiation (LNI). After a median follow-up of 77 months, the 5-year overall and progression free survival were 65% and 57%. Twelve patients (28%) had a locoregional relapse leading to 10 ENB-related deaths. The major prognostic factor was the modified Kadish stage with a 3-year survival for stage A-B, C and D of 100%, 48% and 22% respectively (p < 0.0001). Two (9%) isolated cervical lymph node relapses occurred among staged B and C patients treated without elective LNI and none after elective or adjuvant LNI. Conclusion The high risk of locoregional failure in ENB justifies the use of multimodal therapy. Induction chemotherapy leads to a high response rate. Elective LNI might prevent regional failure in locally advanced disease.
KW - Concurrent chemotherapy
KW - Elective neck irradiation
KW - Esthesioneuroblastoma
KW - Intensity Modulated Radiation Therapy
KW - Neo-adjuvant chemotherapy
KW - Olfactory neuroblastoma
UR - http://www.scopus.com/inward/record.url?scp=84880051558&partnerID=8YFLogxK
U2 - 10.1016/j.oraloncology.2013.04.013
DO - 10.1016/j.oraloncology.2013.04.013
M3 - Article
C2 - 23747132
AN - SCOPUS:84880051558
SN - 1368-8375
VL - 49
SP - 830
EP - 834
JO - Oral Oncology
JF - Oral Oncology
IS - 8
ER -