Next-generation androgen receptor inhibitors in non-metastatic castration-resistant prostate cancer

Pernelle Lavaud, Clément Dumont, Constance Thibault, Laurence Albiges, Giulia Baciarello, Emeline Colomba, Ronan Flippot, Alina Fuerea, Yohann Loriot, Karim Fizazi

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    13 Citations (Scopus)

    Abstract

    Until recently, continuing androgen deprivation therapy (ADT) and closely monitoring patients until evolution towards metastatic castration-resistant prostate cancer (CRPC) were recommended in men with non-metastatic CRPC (nmCRPC). Because delaying the development of metastases and symptoms in these patients is a major issue, several trials have investigated next-generation androgen receptor (AR) axis inhibitors such as apalutamide, darolutamide, and enzalutamide in this setting. This review summarizes the recent advances in the management of nmCRPC, highlighting the favourable impact of next-generation AR inhibitors on metastases-free survival, overall survival and other clinically meaningful endpoints.

    Original languageEnglish
    JournalTherapeutic Advances in Medical Oncology
    Volume12
    DOIs
    Publication statusPublished - 1 Jan 2020

    Keywords

    • apalutamide
    • castration resistance
    • darolutamide
    • enzalutamide
    • next generation androgen receptor inhibitors
    • non-metastatic setting
    • prostate cancer

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