Abstract
Papillary thyroid carcinomas are characterized in 70% of cases by the presence of either a RET/PTC rearrangement, or an activating point mutation of RAS or BRAF genes that induce a constitutive activation of the MAP kinase pathway. Follicular carcinomas are characterized by the presence of a RAS mutation or of a PAX8-PPARγ rearrangement. Inactivating mutations of the p53 gene are found only in anaplastic thyroid carcinomas.
| Translated title of the contribution | Oncogenes and thyroid tumors |
|---|---|
| Original language | French |
| Pages (from-to) | 37-43 |
| Number of pages | 7 |
| Journal | Bulletin du Cancer |
| Volume | 92 |
| Issue number | 1 |
| Publication status | Published - 1 Jan 2005 |