TY - JOUR
T1 - Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
AU - Merad, Miriam
AU - Ginhoux, Florent
AU - Collin, Matthew
N1 - Funding Information:
We are grateful to R. Steinman, N. Romani, M. Udey and J. Helft for the critical review of the manuscript. We thank P. and E. Kontoyannis for their continuous support of Langerhans and Langerhans-cell histiocytosis research. We apologize to the colleagues whose work we have failed to cite owing to space limitations. M.M. is supported by the National Institutes of Health (grant numbers R01CA1121100 and R01AI0086899). F.G. is supported by the leukemia and the lymphoma research foundation.
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans. In recent years, new mouse models have led to the identification of other langerin+ DC subsets that are not present in the epidermis, including a subset of DCs that is found in most non-lymphoid tissues. In this Review we describe new developments in the understanding of the biology of LCs and other langerin+ DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity.
AB - Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans. In recent years, new mouse models have led to the identification of other langerin+ DC subsets that are not present in the epidermis, including a subset of DCs that is found in most non-lymphoid tissues. In this Review we describe new developments in the understanding of the biology of LCs and other langerin+ DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity.
UR - http://www.scopus.com/inward/record.url?scp=56749152272&partnerID=8YFLogxK
U2 - 10.1038/nri2455
DO - 10.1038/nri2455
M3 - Review article
C2 - 19029989
AN - SCOPUS:56749152272
SN - 1474-1733
VL - 8
SP - 935
EP - 947
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 12
ER -