Os et thérapies moléculaires ciblées: Nouveaux agents

Claire Barth; Christophe Massard; Stéphane Vignot

doi:10.1684/met.2014.0447

Os et thérapies moléculaires ciblées: Nouveaux agents

Translated title of the contribution: Bone targeted therapies: New agents

Claire Barth, Christophe Massard, Stéphane Vignot

Research output: Contribution to journal › Article › peer-review

Abstract

The development of bisphosphonates and anti-RANK/RANKL agents was associated with a better understanding of physiological and pathological processes of bone remodeling. New agents are now developed in this context targeting factors associated with osteoclastogenesis (TGFβ, PTHrP), with signaling pathways activated during bone remodeling (Src, Cathepsin K) or with tumor cells homing into bone (chemokines). This review aims to present the underlying rationale for these developments as well as the clinical results. The emergence of new bone targeting therapies is discussed.

Translated title of the contribution	Bone targeted therapies: New agents
Original language	French
Pages (from-to)	118-124
Number of pages	7
Journal	Medecine Therapeutique
Volume	20
Issue number	2
DOIs	https://doi.org/10.1684/met.2014.0447
Publication status	Published - 1 Jan 2014

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Os et thérapies moléculaires ciblées: Nouveaux agents

Abstract

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