TY - JOUR
T1 - Outcomes in N3 Head and Neck Squamous Cell Carcinoma and Role of Upfront Neck Dissection
AU - Boros, Angela
AU - Blanchard, Pierre
AU - Dade, Arlette
AU - Gorphe, Philippe
AU - Breuskin, Ingrid
AU - Even, Caroline
AU - Nguyen, France
AU - Deutsch, Eric
AU - Bidault, François
AU - Janot, François
AU - Temam, Stephane
AU - Mirghani, Haitham
AU - Tao, Yungan
N1 - Publisher Copyright:
© 2020 The American Laryngological, Rhinological and Otological Society, Inc.
PY - 2021/3/1
Y1 - 2021/3/1
N2 - Objectives: We investigated the prognostic factor of N3 head and neck squamous cell carcinoma (HNSCC), including the role of upfront neck dissection (UFND) before radiotherapy (RT). Methods: We retrospectively reviewed the charts of consecutive N3 HNSCC patients treated with curative intent RT. Results: In the study, 323 N3 HNSCC patients were included. Of those, 125 patients (39%) had UFND. Median follow-up was 3.9 years (0–14.8 years). Overall survival (OS) at 5 years was 31.2%, and progression-free survival (PFS) was 26%. In the multivariate analysis, OS was improved in PS 0, T1-2 tumors, patients receiving concurrent chemotherapy, never or former smokers, and UFND. UFND was strongly associated with increased OS (45.7% vs. 21.2%, P <.001), and PFS (P <.001). Regardless of neck node size, UFND improved survival (P =.001 for ≤ 7 cm and P =.004 for > 7 cm). Conclusion: UFND could improve treatment outcomes in N3 HNSCC, especially for non-oropharyngeal cancer, regardless of neck node size. Level of Evidence: 2B Laryngoscope, 131:E844–E850, 2021.
AB - Objectives: We investigated the prognostic factor of N3 head and neck squamous cell carcinoma (HNSCC), including the role of upfront neck dissection (UFND) before radiotherapy (RT). Methods: We retrospectively reviewed the charts of consecutive N3 HNSCC patients treated with curative intent RT. Results: In the study, 323 N3 HNSCC patients were included. Of those, 125 patients (39%) had UFND. Median follow-up was 3.9 years (0–14.8 years). Overall survival (OS) at 5 years was 31.2%, and progression-free survival (PFS) was 26%. In the multivariate analysis, OS was improved in PS 0, T1-2 tumors, patients receiving concurrent chemotherapy, never or former smokers, and UFND. UFND was strongly associated with increased OS (45.7% vs. 21.2%, P <.001), and PFS (P <.001). Regardless of neck node size, UFND improved survival (P =.001 for ≤ 7 cm and P =.004 for > 7 cm). Conclusion: UFND could improve treatment outcomes in N3 HNSCC, especially for non-oropharyngeal cancer, regardless of neck node size. Level of Evidence: 2B Laryngoscope, 131:E844–E850, 2021.
KW - Head and neck cancer
KW - N3
KW - chemoradiotherapy
KW - neck dissection
UR - http://www.scopus.com/inward/record.url?scp=85089742321&partnerID=8YFLogxK
U2 - 10.1002/lary.28893
DO - 10.1002/lary.28893
M3 - Article
C2 - 32833260
AN - SCOPUS:85089742321
SN - 0023-852X
VL - 131
SP - E846-E850
JO - Laryngoscope
JF - Laryngoscope
IS - 3
ER -