Paraneoplastic fibrillary glomerulonephritis associated with intrahepatic cholangiocarcinoma: When diagnosis of a rare kidney disease leads to successful hepatic cancer treatment

Gabrielle Normand; Anne Jolivot; Maud Rabeyrin; Valérie Hervieu; Pierre Jean Valette; Jean Yves Scoazec; Jean Michel Gougon; Laurent Juillard; Jérôme Dumortier

doi:10.1016/j.clinre.2016.07.002

Paraneoplastic fibrillary glomerulonephritis associated with intrahepatic cholangiocarcinoma: When diagnosis of a rare kidney disease leads to successful hepatic cancer treatment

Gabrielle Normand, Anne Jolivot, Maud Rabeyrin, Valérie Hervieu, Pierre Jean Valette, Jean Yves Scoazec, Jean Michel Gougon, Laurent Juillard, Jérôme Dumortier

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A 50-year-old man presented with nephrotic syndrome. Electron microscopy analysis of a kidney biopsy specimen showed fibrillary glomerulonephritis, a rare glomerular disease, while histological analysis of a liver tumor biopsy confirmed an intrahepatic cholangiocarcinoma. The paraneoplastic nature of fibrillary glomerulonephritis is debated but after curative treatment of the hepatic nodule, remission of nephrotic syndrome was confirmed at 6-, 12- and 24-months follow-up. To our knowledge, this is the first description of a paraneoplastic fibrillary glomerulonephritis associated with a cholangiocarcinoma, supported by complete remission achieved following cancer treatment.

Original language	English
Pages (from-to)	e8-e11
Journal	Clinics and Research in Hepatology and Gastroenterology
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/j.clinre.2016.07.002
Publication status	Published - 1 Feb 2017
Externally published	Yes

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10.1016/j.clinre.2016.07.002

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Normand, G., Jolivot, A., Rabeyrin, M., Hervieu, V., Valette, P. J., Scoazec, J. Y., Gougon, J. M., Juillard, L., & Dumortier, J. (2017). Paraneoplastic fibrillary glomerulonephritis associated with intrahepatic cholangiocarcinoma: When diagnosis of a rare kidney disease leads to successful hepatic cancer treatment. Clinics and Research in Hepatology and Gastroenterology, 41(1), e8-e11. https://doi.org/10.1016/j.clinre.2016.07.002

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abstract = "A 50-year-old man presented with nephrotic syndrome. Electron microscopy analysis of a kidney biopsy specimen showed fibrillary glomerulonephritis, a rare glomerular disease, while histological analysis of a liver tumor biopsy confirmed an intrahepatic cholangiocarcinoma. The paraneoplastic nature of fibrillary glomerulonephritis is debated but after curative treatment of the hepatic nodule, remission of nephrotic syndrome was confirmed at 6-, 12- and 24-months follow-up. To our knowledge, this is the first description of a paraneoplastic fibrillary glomerulonephritis associated with a cholangiocarcinoma, supported by complete remission achieved following cancer treatment.",

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Normand, G, Jolivot, A, Rabeyrin, M, Hervieu, V, Valette, PJ, Scoazec, JY, Gougon, JM, Juillard, L & Dumortier, J 2017, 'Paraneoplastic fibrillary glomerulonephritis associated with intrahepatic cholangiocarcinoma: When diagnosis of a rare kidney disease leads to successful hepatic cancer treatment', Clinics and Research in Hepatology and Gastroenterology, vol. 41, no. 1, pp. e8-e11. https://doi.org/10.1016/j.clinre.2016.07.002

Paraneoplastic fibrillary glomerulonephritis associated with intrahepatic cholangiocarcinoma: When diagnosis of a rare kidney disease leads to successful hepatic cancer treatment. / Normand, Gabrielle; Jolivot, Anne; Rabeyrin, Maud et al.
In: Clinics and Research in Hepatology and Gastroenterology, Vol. 41, No. 1, 01.02.2017, p. e8-e11.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Paraneoplastic fibrillary glomerulonephritis associated with intrahepatic cholangiocarcinoma

T2 - When diagnosis of a rare kidney disease leads to successful hepatic cancer treatment

AU - Normand, Gabrielle

AU - Jolivot, Anne

AU - Rabeyrin, Maud

AU - Hervieu, Valérie

AU - Valette, Pierre Jean

AU - Scoazec, Jean Yves

AU - Gougon, Jean Michel

AU - Juillard, Laurent

AU - Dumortier, Jérôme

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AB - A 50-year-old man presented with nephrotic syndrome. Electron microscopy analysis of a kidney biopsy specimen showed fibrillary glomerulonephritis, a rare glomerular disease, while histological analysis of a liver tumor biopsy confirmed an intrahepatic cholangiocarcinoma. The paraneoplastic nature of fibrillary glomerulonephritis is debated but after curative treatment of the hepatic nodule, remission of nephrotic syndrome was confirmed at 6-, 12- and 24-months follow-up. To our knowledge, this is the first description of a paraneoplastic fibrillary glomerulonephritis associated with a cholangiocarcinoma, supported by complete remission achieved following cancer treatment.

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Normand G, Jolivot A, Rabeyrin M, Hervieu V, Valette PJ, Scoazec JY et al. Paraneoplastic fibrillary glomerulonephritis associated with intrahepatic cholangiocarcinoma: When diagnosis of a rare kidney disease leads to successful hepatic cancer treatment. Clinics and Research in Hepatology and Gastroenterology. 2017 Feb 1;41(1):e8-e11. doi: 10.1016/j.clinre.2016.07.002

Paraneoplastic fibrillary glomerulonephritis associated with intrahepatic cholangiocarcinoma: When diagnosis of a rare kidney disease leads to successful hepatic cancer treatment

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