Pathophysiology of Cancer Cell Death

Lorenzo Galluzzi; Andreas Linkermann; Oliver Kepp; Guido Kroemer

doi:10.1016/B978-0-323-47674-4.00005-0

Pathophysiology of Cancer Cell Death

Lorenzo Galluzzi, Andreas Linkermann, Oliver Kepp, Guido Kroemer

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Citations (Scopus)

Abstract

Malignant transformation, tumor progression and resistance to cancer therapy often occur in the context of disabled cell death signaling. Here we describe the major mechanisms of cell death regulation in mammalian cells and discuss the pathophysiologic and therapeutic implications of their deregulation in the course of oncogenesis.

Original language	English
Title of host publication	Abeloff’s Clinical Oncology
Publisher	Elsevier
Pages	74-83.e4
ISBN (Electronic)	9780323476744
DOIs	https://doi.org/10.1016/B978-0-323-47674-4.00005-0
Publication status	Published - 1 Jan 2019
Externally published	Yes

Keywords

Apoptosis
Bcl-2 proteins
Caspases
MPT-driven regulated necrosis
NF-κB
Necroptosis
Pyroptosis

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10.1016/B978-0-323-47674-4.00005-0

Cite this

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title = "Pathophysiology of Cancer Cell Death",

abstract = "Malignant transformation, tumor progression and resistance to cancer therapy often occur in the context of disabled cell death signaling. Here we describe the major mechanisms of cell death regulation in mammalian cells and discuss the pathophysiologic and therapeutic implications of their deregulation in the course of oncogenesis.",

keywords = "Apoptosis, Bcl-2 proteins, Caspases, MPT-driven regulated necrosis, NF-κB, Necroptosis, Pyroptosis",

author = "Lorenzo Galluzzi and Andreas Linkermann and Oliver Kepp and Guido Kroemer",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2019",

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doi = "10.1016/B978-0-323-47674-4.00005-0",

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T1 - Pathophysiology of Cancer Cell Death

AU - Galluzzi, Lorenzo

AU - Linkermann, Andreas

AU - Kepp, Oliver

AU - Kroemer, Guido

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Malignant transformation, tumor progression and resistance to cancer therapy often occur in the context of disabled cell death signaling. Here we describe the major mechanisms of cell death regulation in mammalian cells and discuss the pathophysiologic and therapeutic implications of their deregulation in the course of oncogenesis.

AB - Malignant transformation, tumor progression and resistance to cancer therapy often occur in the context of disabled cell death signaling. Here we describe the major mechanisms of cell death regulation in mammalian cells and discuss the pathophysiologic and therapeutic implications of their deregulation in the course of oncogenesis.

KW - Apoptosis

KW - Bcl-2 proteins

KW - Caspases

KW - MPT-driven regulated necrosis

KW - NF-κB

KW - Necroptosis

KW - Pyroptosis

UR - http://www.scopus.com/inward/record.url?scp=85084512577&partnerID=8YFLogxK

U2 - 10.1016/B978-0-323-47674-4.00005-0

DO - 10.1016/B978-0-323-47674-4.00005-0

M3 - Chapter

AN - SCOPUS:85084512577

SP - 74-83.e4

BT - Abeloff’s Clinical Oncology

PB - Elsevier

ER -

Pathophysiology of Cancer Cell Death

Abstract

Keywords

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