@article{e3db8bfc6cf04853a972f188d7a02605,
title = "Pediatric low-grade gliomas: How modern biology reshapes the clinical field",
abstract = "Low-grade gliomas represent the most frequent brain tumors arising during childhood. They are characterized by a broad and heterogeneous group of tumors that are currently classified by the WHO according to their morphological appearance. Here we review the clinical features of these tumors, current therapeutic strategies and the recent discovery of genomic alterations characteristic to these tumors. We further explore how these recent biological findings stand to transform the treatment for these tumors and impact the diagnostic criteria for pediatric low-grade gliomas.",
keywords = "BRAF, Genetics, Low-grade glioma, Pediatric",
author = "Guillaume Bergthold and Pratiti Bandopadhayay and Bi, {Wenya Linda} and Lori Ramkissoon and Charles Stiles and Segal, {Rosalind A.} and Rameen Beroukhim and Ligon, {Keith L.} and Jacques Grill and Kieran, {Mark W.}",
note = "Funding Information: Pediatric Low-Grade Astrocytoma Foundation (GB, PB, RB, LR, RAS, CS and MWK), Stop&Shop Pediatric Brain Tumor Program (PB and MWK), Andrysiak Fund for LGG (MWK), Nuovo-Soldati Foundation (GB), Philippe Foundation (GB), Friends of DFCI (GB and PB),Team Jack Foundation (PB, CS and MWK), the Mill Foundation for Kids (MWK), the Sontag Foundation (RB), Gray Matters Foundation (RB), NIH PO1CA142536 (RAS), NIH PO1NS047572 (CS), INCA grant PHRC 2008 (JG), L{\textquoteright}Etoile de Martin (JG).",
year = "2014",
month = jan,
day = "1",
doi = "10.1016/j.bbcan.2014.02.004",
language = "English",
volume = "1845",
pages = "294--307",
journal = "Biochimica et Biophysica Acta - Reviews on Cancer",
issn = "0304-419X",
number = "2",
}