Pharmacological inhibition of programmed lymphocyte death

Guido Kroemer; Carlos Martínez-A

doi:10.1016/0167-5699(94)90249-6

Pharmacological inhibition of programmed lymphocyte death

Guido Kroemer, Carlos Martínez-A

Research output: Contribution to journal › Review article › peer-review

72 Citations (Scopus)

Abstract

Programmed cell death (PCD) is a necessary process that helps to regulate the lifespan of lymphocytes and maintain the compartmental balance of lymphoid organs. In addition, PCD is required for the generation and maintenance of self-tolerance. Strategies that inhibit PCD cause profound alternations in the (patho)physiology of the immune system. Here, Guido Kroemer and Carlos Martínez-A. discuss the multiplicity of PCD-inducing pathways, which have been revealed through the use of PCD-inhibitory agents, and analyse the levels at which these agents act.

Original language	English
Pages (from-to)	235-242
Number of pages	8
Journal	Immunology Today
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/0167-5699(94)90249-6
Publication status	Published - 1 Jan 1994
Externally published	Yes

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title = "Pharmacological inhibition of programmed lymphocyte death",

abstract = "Programmed cell death (PCD) is a necessary process that helps to regulate the lifespan of lymphocytes and maintain the compartmental balance of lymphoid organs. In addition, PCD is required for the generation and maintenance of self-tolerance. Strategies that inhibit PCD cause profound alternations in the (patho)physiology of the immune system. Here, Guido Kroemer and Carlos Mart{\'i}nez-A. discuss the multiplicity of PCD-inducing pathways, which have been revealed through the use of PCD-inhibitory agents, and analyse the levels at which these agents act.",

author = "Guido Kroemer and Carlos Mart{\'i}nez-A",

note = "Funding Information: We thank J.A. Gonzalo and A. Gonz~lez-Garcia for allowing us to quote their unpublished work. This work was supported by the ARC, FNRM, EC, CICyT and Kabi Pharmacia.",

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AU - Kroemer, Guido

AU - Martínez-A, Carlos

N1 - Funding Information: We thank J.A. Gonzalo and A. Gonz~lez-Garcia for allowing us to quote their unpublished work. This work was supported by the ARC, FNRM, EC, CICyT and Kabi Pharmacia.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Programmed cell death (PCD) is a necessary process that helps to regulate the lifespan of lymphocytes and maintain the compartmental balance of lymphoid organs. In addition, PCD is required for the generation and maintenance of self-tolerance. Strategies that inhibit PCD cause profound alternations in the (patho)physiology of the immune system. Here, Guido Kroemer and Carlos Martínez-A. discuss the multiplicity of PCD-inducing pathways, which have been revealed through the use of PCD-inhibitory agents, and analyse the levels at which these agents act.

AB - Programmed cell death (PCD) is a necessary process that helps to regulate the lifespan of lymphocytes and maintain the compartmental balance of lymphoid organs. In addition, PCD is required for the generation and maintenance of self-tolerance. Strategies that inhibit PCD cause profound alternations in the (patho)physiology of the immune system. Here, Guido Kroemer and Carlos Martínez-A. discuss the multiplicity of PCD-inducing pathways, which have been revealed through the use of PCD-inhibitory agents, and analyse the levels at which these agents act.

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U2 - 10.1016/0167-5699(94)90249-6

DO - 10.1016/0167-5699(94)90249-6

M3 - Review article

C2 - 8024684

AN - SCOPUS:42549173580

SN - 0167-5699

VL - 15

SP - 235

EP - 242

JO - Immunology Today

JF - Immunology Today

IS - 5

ER -

Pharmacological inhibition of programmed lymphocyte death

Abstract

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