TY - JOUR
T1 - Phenotypic and functional characterization of first-trimester human placental macrophages, Hofbauer cells
AU - Thomas, Jake R.
AU - Appios, Anna
AU - Zhao, Xiaohui
AU - Dutkiewicz, Roksana
AU - Donde, Maria
AU - Lee, Colin Y.C.
AU - Naidu, Praveena
AU - Lee, Christopher
AU - Cerveira, Joana
AU - Liu, Bing
AU - Ginhoux, Florent
AU - Burton, Graham
AU - Hamilton, Russell S.
AU - Moffett, Ashley
AU - Sharkey, Andrew
AU - McGovern, Naomi
N1 - Publisher Copyright:
© 2020 Thomas et al.
PY - 2020/10/19
Y1 - 2020/10/19
N2 - Hofbauer cells (HBCs) are a population of macrophages found in high abundance within the stroma of the first-trimester human placenta. HBCs are the only fetal immune cell population within the stroma of healthy placenta. However, the functional properties of these cells are poorly described. Aligning with their predicted origin via primitive hematopoiesis, we find that HBCs are transcriptionally similar to yolk sac macrophages. Phenotypically, HBCs can be identified as HLA-DR−FOLR2+ macrophages. We identify a number of factors that HBCs secrete (including OPN and MMP-9) that could affect placental angiogenesis and remodeling. We determine that HBCs have the capacity to play a defensive role, where they are responsive to Toll-like receptor stimulation and are microbicidal. Finally, we also identify a population of placenta-associated maternal macrophages (PAMM1a) that adhere to the placental surface and express factors, such as fibronectin, that may aid in repair.
AB - Hofbauer cells (HBCs) are a population of macrophages found in high abundance within the stroma of the first-trimester human placenta. HBCs are the only fetal immune cell population within the stroma of healthy placenta. However, the functional properties of these cells are poorly described. Aligning with their predicted origin via primitive hematopoiesis, we find that HBCs are transcriptionally similar to yolk sac macrophages. Phenotypically, HBCs can be identified as HLA-DR−FOLR2+ macrophages. We identify a number of factors that HBCs secrete (including OPN and MMP-9) that could affect placental angiogenesis and remodeling. We determine that HBCs have the capacity to play a defensive role, where they are responsive to Toll-like receptor stimulation and are microbicidal. Finally, we also identify a population of placenta-associated maternal macrophages (PAMM1a) that adhere to the placental surface and express factors, such as fibronectin, that may aid in repair.
UR - http://www.scopus.com/inward/record.url?scp=85096309639&partnerID=8YFLogxK
U2 - 10.1084/JEM.20192386
DO - 10.1084/JEM.20192386
M3 - Article
C2 - 33045064
AN - SCOPUS:85096309639
SN - 0022-1007
VL - 218
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 1
M1 - e20200891
ER -