Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death

Maria Castedo; Antoine Lafarge; Guido Kroemer

doi:10.15698/cst2023.01.275

Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death

Maria Castedo, Antoine Lafarge, Guido Kroemer

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The deletion of the gene coding for poly(ADP-ribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson’s disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of vulnerable cancer cells. It appears that excessive PARP1 activation is involved in a specific cell death pathway called parthanatos, while inhibition of PARP1 in cancer cells amplifies DNA damage to a lethal level. Hence, PARP1 plays a context-dependent role in cell fate decisions. In addition, it appears that PARP1 plays an ambiguous role in organismal aging.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Cell Stress
Volume	7
Issue number	1
DOIs	https://doi.org/10.15698/cst2023.01.275
Publication status	Published - 1 Jan 2023

Keywords

DNA damage
PARP1 inhibition
aging
cancer
cellular stress response
neurological diseases
parthanatos

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10.15698/cst2023.01.275

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abstract = "The deletion of the gene coding for poly(ADP-ribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson{\textquoteright}s disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of vulnerable cancer cells. It appears that excessive PARP1 activation is involved in a specific cell death pathway called parthanatos, while inhibition of PARP1 in cancer cells amplifies DNA damage to a lethal level. Hence, PARP1 plays a context-dependent role in cell fate decisions. In addition, it appears that PARP1 plays an ambiguous role in organismal aging.",

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AB - The deletion of the gene coding for poly(ADP-ribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson’s disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of vulnerable cancer cells. It appears that excessive PARP1 activation is involved in a specific cell death pathway called parthanatos, while inhibition of PARP1 in cancer cells amplifies DNA damage to a lethal level. Hence, PARP1 plays a context-dependent role in cell fate decisions. In addition, it appears that PARP1 plays an ambiguous role in organismal aging.

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Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death

Abstract

Keywords

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